【摘要】 目的观察老年惊厥性癫痫持续状态(CSE)的临床特点。方法收集神经重症监护室(NICU)年龄≥60岁的CSE患者28例,回顾性分析其临床特点。结果脑血管病为28例老年CSE的首位病因。接受抗癫痫药物治疗后,CSE症状控制的中位时间为0.9 h,其中16例患者在1 h内症状控制,12例为难治性癫痫持续状态(RSE)。28例患者中,存活16例、死亡12例。死亡者与存活者相比,合并中枢神经系统新发疾病(P=0.027)和RSE的比例显著不同(P=0.027)。结论老年CSE患者基础情况差,病因多样,合并有中枢神经系统新发疾病或有RSE者的死亡率高。更多还原

【Abstract】 Objective To observe the clinical characteristics of elderly patients with convulsive status epilepticus( CSE).Methods Retrospectively analyzed the clinical characteristics of 28 aged patients( age above 60) with CSE admitted to our neurological intensive care unit( NICU).Results The most common etiology of CSE in elder patients was cerebrovascular disease.Median time from antiepileptic drugs( AEDs) treatment to CSE successful terminated was 0.9 hour.Among these patients,CSE was terminated successfully in 16 patients within 1 hour,while other 12 patients were in status of refractory status epilepticus( RSE).As a result,16 patients survived and 12 died.Compared died patients with those survived,the rates of new-onset central nervous system lesions( P = 0.027) and RSE( P = 0.027) were significantly different.Conclusion The elderly patients with CSE have poor health basis and various etiologies of CSE.Presenting of new-onset of central nervous system lesions and RSE are associated with the increased rate of death.更多还原