【摘要】 目的探讨儿童深部真菌感染情况,分析其对常用抗真菌药物的敏感性,为真菌感染的治疗和预防提供依据。方法回顾性分析了2009年3月~2012年12月延安大学附属医院270例确诊为深部真菌感染住院患儿的临床资料,药敏试验严格按照2006年CLSI M272A2规则及标准进行AmB、FCZ,5-FC、ICZ 4种抗真菌药敏检测。结果真菌感染样本主要来源于咽拭子,白假丝酵母的分离率最高61.11%,其次为光滑假丝酵母菌、热带假丝酵母菌、近平滑假丝酵母菌和克柔假丝酵母菌。药敏实验结果表明,假丝酵母菌对AmB、5-FC的敏感性较高。儿科患者中分离的真菌中以假丝酵母菌属最多,并以白假丝酵母菌为主。AmB、5-FC均有较高的抗真菌活性。结论应加强对临床真菌感染与耐药性情况的监测,以指导临床合理使用抗生素。更多还原

【Abstract】 Objective To investigate the distribution and drug resistance of deep fungal infection in children and provide a basis for the treatment and prevention of fungal infection. Methods The data of 270 cases with deep fungal infection were retrospectively analyzed from March 2009 to December 2012 in a hospital of Yan’an City.The susceptibility to Am B, FCZ, 5-FC, ICZ were analyzed according to the guidelines of CLSI(Clinical and Laboratory Standard Institute) M272A2.Results The specimens were collected from nasopharyngeal swabs. The isolation rate of Candida albicans was the highest(61.11%),followed by Candida glabrata,Candida tropicalis,Candida parapsilosis and Candida krusei. The results of drug sensitive test showed that the sensitivities of Candida to amphotericin B and 5-fluorouracil were high.Candida strains,especially Candida albicans, were most common species in children with fungal infection. 5-fluorocytosine and amphotericin B were effective on deep fungal infection.Conclusions Monitoring of clinical fungus infection and its drug- resistance be enhanced in order to guide the reasonable clinical use of antibiotics.更多还原