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肝吸虫病常用诊断方法的效果评估

Evaluation on regular diagnostic methods for clonorchiasis

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【作者】 张晓丽陈小贝朱骥伟舒晶韩甦

【Author】 Zhang Xiaoli;Chen Xiaobei;Zhu Jiwei;Shu Jing;Han Su;Department of Parasitology,Haerbin Medical University;Center of Laboratory,Haerbin Medical University;Department of Forensic,Haerbin Medical University;

【机构】 哈尔滨医科大学寄生虫学教研室哈尔滨医科大学检验中心哈尔滨医科大学法医学教研室

【摘要】 目的评估酶联免疫方法用于辅助诊断肝吸虫病的效果。方法采用酶联免疫方法(ELISA)和Kato-Katz方法,对2009~2010年在哈尔滨医科大学人体寄生虫病研究所就诊的疑似肝吸虫病患者进行检测,利用贝叶斯统计方法计算ELISA和Kato-Katz方法的敏感性和特异性。结果共对2359人临床疑诊为肝吸虫病患者进行了了检测。酶联免疫方法(ELISA)检测抗体阳性率40.44%(954/2359),Ka的-Katz方法粪便中虫卵检出率为21.75%(513/2 359),血清ELISA阳性率明显高于粪便虫卵检出率(P<0.05)。其中,血清ELISA方法敏感性为98.7%、特异性为76.53%、阳性预测值为54.66%、阴性预测值达99.52%,与粪便虫卵检出法的吻合度系数为0.564。结论粪便检查联合血清ELISA法可用于提高肝吸虫病的诊断率。

【Abstract】 Objective To evaluate the effect on the diagnosis of clonorchiasis by enzyme- linked immunosorbent assays(ELISA) as a supplementary method.Methods From 2009 to 2010,the patients with suspected clonorchiasis visited to institute of parasitology,Haerbin medical university were determined with the ethod of ELISA and Kato- katz.Statistic method of Bayesian was used to calculate the sensitivity and specificity.Results The total of 2 359 patients with suspected clonorchiasis were determined.The antibodypositive rate determined by ELISA was 40.44%(954/2 359),and the egg-positive rate found by examination of feces was 21.75%(513/2 359).The positive rate of ELISA was significandy higher than that of Kato-katz(P<0.05).The sensitivity,specificity,positive predictive value and negative predictive value of ELISA were 98.7%,76.53%>,54.66%and 99.52%,respectively.The agreement between the two methods was 0.564.Conclusion The combination of ELISA and Kato-katz could improve the diagnostic accuracy of clonorchiasis.

【关键词】 肝吸虫病诊断ELISAKato-Katz
【Key words】 ClonorchiasisDiagnosisELISAKato-Katz
【基金】 黑龙江省教育厅资助项目(12531347)
  • 【文献出处】 热带病与寄生虫学 ,Journal of Tropical Diseases and Parasitology , 编辑部邮箱 ,2014年01期
  • 【分类号】R532.2
  • 【被引频次】3
  • 【下载频次】253
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