【摘要】 目的探讨氨磺必利对度洛西汀治疗老年期抑郁症的辅助作用。方法采用随机开放对照研究,将60例诊断为老年期抑郁症的患者随机分为实验组30例(氨磺必利联合度洛西汀治疗)与对照组30例(单纯度洛西汀治疗),分别在治疗前及治疗后第2、4、6、8周末,采用汉密尔顿抑郁量表(HAMD-17)、临床总体印象量表(CGI)评定治疗效果,并采用Asberg抗抑郁剂副反应量表(SERS)评定两组的药物副反应。结果 (1)经治疗后,自第2周末起两组被试HAMD评分明显低于治疗前(均P<0.05),且自第4周末起,实验组评分低于对照组(均P<0.05);(2)经治疗后两组CGI-GI评分均明显降低(均P<0.05),自第4周末起,实验组评分低于对照组;(3)治疗后第8周末,两组SERS评分差异无统计学意义(P>0.05)。结论小剂量氨磺必利对度洛西汀治疗老年期抑郁症有增效作用,且不增加副作用的发生。更多还原

【Abstract】 Objective To explore the assistant effect of amisulpride in the treatment of elderly depression with duloxetine. Methods 60 patients( ≥60 years old) met with CCMD- 3 criteria for depression disorder were randomly allocated to the treatment group( treated with low dose of amisulpride combined with duloxetine,n =30) and control group( treated with duloxetine alone,n = 30). All subjects were assessed with Hamilton Rating Scale for Depression( HAMD- 17),Clinical Global Impression( CGI) and Asberg Rating Scale for Side Effects( SERS) was used to evaluate the efficacy and side effects at time points before and 2,4,6 and 8 weeks after treatment. Results The HAMD scores significantly decreased from the end of week- 2 inboth group after treatment( P < 0. 05),and the HAMD scores of the trial group were continuously lower than that of control group from the end of week- 4( P < 0. 05). The CGI- GI scores significantly decreased in both group after treatment( P < 0. 05),and the score of trial group were continuously lower than that of control group from the end of week- 4( P < 0. 05). The SERS score was not significantly difference between the two groups( P > 0. 05).Conclusions Low dose of amisulpride can augment the effect of duloxetine for the treatment of the elderly depression,and demonstrates equivalent safety with duloxetine treatment alone.更多还原