【摘要】 目的探讨血清铁蛋白(serum ferritin,SF)在多发性骨髓瘤(multiple myeloma,MM)患者中的变化及临床意义。方法选择30例多发性骨髓瘤患者(MM组)和30名健康志愿者(对照组)作为研究对象,检测其SF、血清β2-微球蛋白(β2-microglobulin,β2-MG)和乳酸脱氢酶(lactate dehydrogenase,LDH)的水平,并对检测结果和阳性检出率进行统计分析。结果 MM组的SF水平(613.6±274.6μg/L)明显高于对照组(131.8±59.0μg/L),差异具有统计学意义(P<0.01)。MM组SF与血清β2-MG水平呈明显正相关(r=0.545,P<0.01);而与血清LDH水平无明显相关(r=0.349,P>0.05)。MM组患者SF的阳性检出率与血清β2-MG之间没有显著性差异(χ2=1.071,P>0.05);而SF的阳性检出率明显高于血清LDH,差异具有统计学意义(χ2=18.373,P<0.01)。结论多发性骨髓瘤患者SF水平明显升高;SF和血清β2-MG水平呈明显正相关,且二者阳性检出率相近。SF对多发性骨髓瘤的辅助诊断有一定参考价值。更多还原

【Abstract】 Objective To discuss the clinical significance of serum ferritin( SF) in patients suffered from multiple myeloma( MM). Methods Detectthe levels of SF,β2- microglobulin( β2- MG) and lactate dehydrogenase( LDH) in serumfor 30 patients with MM and 30 healthy volunteersrespectively. The data was analyzed by IBM SPSS Statistics. Results The SFlevels in patients with MM( 613. 6 ± 274. 6μg / L) were significantly higher than those in normal controls( 131. 8 ± 59. 0μg / L)( P < 0. 01). SF levels positively correlated to β2- MG levels in MM group( r = 0. 545,P < 0. 01),but the positive rates were close with each other( χ2= 1. 071,P > 0. 05). The relationship between SF and LDH levels present no statistically significant( r = 0. 349,P > 0. 05),but the positive rates are statistically different( χ2= 18. 373,P < 0. 01). Conclusions The SFlevels were increased in patients with MM. SF levels positively correlated to β2- MG levels,and the positive rates were close to each other. SF might be used as a assistant diagnosis for diagnosing multiple myeloma.更多还原