【摘要】 目的对比国际预后指数(IPI)与套细胞淋巴瘤国际预后指数(MIPI)对套细胞淋巴瘤(MCL)患者的预测效能。方法收集广西柳州市人民医院2001年12月—2011年12月收治的MCL患者21例,进行IPI评分和MIPI评分,采用Kappa检验分析两者的一致性;采用log-rank检验比较不同性别、年龄、乳酸脱氢酶(LDH)、IPI评分、MIPI评分及有无骨髓侵犯、B症状MCL患者的总生存时间。结果 21例MCL患者中男15例、女6例,中位年龄55岁,有骨髓侵犯10例。IPI评分结果:低危3例,低中危5例,高中危8例,高危5例;MIPI评分结果:低危6例,中危4例,高危11例。Kappa检验结果显示,IPI评分与MIPI评分一致性较好(Kappa=0.547,P=0.010)。所有患者随访至2013-05-30,随访时间为3~120个月,中位随访时间为32个月。不同性别〔男性(67.5±15.4)个月,女性(37.8±16.0)个月〕、年龄〔<60岁(73.1±16.4)个月,≥60岁(25.1±4.9)个月〕、LDH〔<240 U/L(73.6±15.8)个月,≥240 U/L(35.6±13.5)个月〕、MIPI评分〔低危(90.4±16.5)个月,中危(28.3±5.8)个月,高危(23.4±4.4)个月〕及有无B症状〔有(29.2±6.8)个月,无(85.8±16.0)个月〕、有无骨髓侵犯〔有(23.4±4.3)个月,无(72.6±15.4)个月〕MCL患者总生存时间比较,差异均无统计学意义(P>0.05);不同IPI评分〔低危+低中危(81.8±16.9)个月,高中危(31.6±4.2)个月,高危(15.0±6.1)个月〕MCL患者总生存时间比较,差异有统计学意义(P<0.05)。结论 IPI与MIPI一致性较好,但本研究并未发现MIPI较IPI对MCL患者总生存时间的预测效能更好。更多还原

【Abstract】 Objective To compare the predicting efficiencies between international prognostic index(IPI) and mantle cell lymphoma international prognostic index(MIPI) in patients with mantle cell lymphoma(MCL).Methods Scores of IPI and MIPI were performed in 21 MCL patients admitted to People’s Hospital of Liuzhou from December 2001 to December 2011.Kappa test was used to analyze their consistency,log-rank test to compare the overall survival time between patients at different ages,with different genders,levels of lactate dehydrogenase(LDH),scores of IPI,MIPI,presence of bone marrow involvement(BMI),B symptoms or not.Results In 21 MCL patients,there were 15 males,6 females;at median age of 55 years;10 had BMI.By IPI score results,3 patients were low-risk,5 low to medium-risk,8 high to medium-risk,5 high-risk;by MIPI score results,6 patients were low-risk,4 medium-risk,11 high-risk.Kappa test showed that IPI scores consisted well with those of MIPI(Kappa=0.547,P=0.010).The follow-ups lasted 3-120 months,the median was 32 months.There was no significant difference in overall survival time between patients at different ages 〔<60 years old:(73.1 ± 16.4)months,≥60:(25.1 ± 4.9) months〕,with different genders 〔males:(67.5 ± 15.4) months,females:(37.8 ± 16.0)months〕,LDH levels〔<240 U /L:(73.6 ± 15.8) months,≥240 U /L:(35.6 ± 13.5) months〕,scores of MIPI 〔low-risk:(90.4 ± 16.5) months,medium-risk:(28.3 ± 5.8) months,high-risk:(23.4 ± 4.4) months〕,with B symptoms or not 〔with B symptom:(29.2 ± 6.8) months,without B symptom:(85.8 ± 16.0) months〕,with BMI or not 〔with BMI:(23.4 ± 4.3) months,without BMI:(72.6 ± 15.4) months〕(P>0.05);there was difference between patients with different IPI scores 〔low-risk+low to medium-risk:(81.8 ± 16.9) months,high to medium-risk:(31.6 ± 4.2) months,high-risk:(15.0 ± 6.1) months〕(P<0.05).Conclusion IPI consist well with MIPI.MIPI is not superior to IPI in predicting efficiency of overall survival time of MCL patients.更多还原