【摘要】 目的探讨宫颈癌患者Th17细胞相关因子与25-羟基维生素D检测的临床价值。方法收集宫颈癌患者68例,其中腺癌28例、鳞状细胞癌40例,选取年龄与其相匹配的50例健康体检者作为对照组。分析25羟维生素D与白介素17(IL-17)、白介素6(IL-6)在各组间的差异及其相关性。结果宫颈癌患者血浆25-羟基维生素D浓度为(24.50±6.80)ng/ml,低于健康对照组(35.10±8.70)ng/ml,宫颈癌患者血浆IL-17浓度为550(350,705)ng/L,IL-6浓度为480(390,620)ng/L,均低于健康对照组,差异有统计学意义(P均<0.05);腺癌患者血浆25-羟基维生素D、IL-17、IL-6浓度与鳞状细胞癌患者比较,差异无统计学意义(P>0.05);宫颈癌患者血浆IL-6、IL-17与25-羟基维生素D存在相关性(r分别=0.37、0.40,P均<0.05)。结论宫颈癌患者血浆25-羟基维生素D与Th17细胞相关因子浓度检测对治疗和预后监测具有一定临床价值。更多还原

【Abstract】 Objective To investigate plasma T helper cell 17 cytokine and 25(OH) vitamin D in patients with cervical cancer and its clinical value. Methods Sixty eight cases with cervical cancer were enrolled, including 28 cases of adenocarcinoma, 40 cases squamous cell carcinoma. Selected age matched 50 healthy volunteers as a control group. 25(OH) vitamin D and T helper cell 17 cytokine in the differences among the groups and their correlation were analyzed. Results Cervical cancer patients plasma 25(OH) vitamin D concentration were(24.50±6.80)ng/ml, lower than the healthy control group(35.10 ±8.70) ng/ml, cervical cancer patients plasma IL-17, IL-6 concentrations were 550(350,705)ng/L,480(390,620)ng/L, lower than the healthy control group, the difference was statistically significant(P<0.05); adenocarcinoma patients plasma 25(OH) vitamin D, IL-17, IL-6 concentrations was not statistically significant difference with patients of squamous cell carcinoma(P>0.05), there was correlation of plasma IL-17, IL-6 and 25(OH) vitamin D in patients with cervical cancer(r=0.37, 0.40, P<0.05). Conclusions Plasma 25(OH) vitamin D and IL-17, IL-6 concentration detection are helpful for monitoring the treatment and prognosis of patients with cervical cancer.更多还原