【摘要】 目的了解大鼠超敏C反应蛋白(hs-CRP)水平与动脉粥样硬化性肾病病程的相关性。方法选取40只大鼠随机分为对照组和模型组。构建动脉粥样硬化性肾病大鼠模型。各组分别于造模0、6、12周测定血脂四项、肾功能及hs-CRP水平;制作主动脉、肾动脉及肾组织切片观察病理变化。结果 6周及12周模型组血清hs-CRP分别为0.015±0.002、0.032±0.006,均高于对照组(P<0.05),尿素氮(BUN)及肌酐(CREA)均明显高于对照组(P<0.05),且hs-CRP与BUN、CREA呈显著正相关,r分别为0.871、0.940(P<0.01)。结论 hs-CRP与动脉粥样硬化性肾病病程相关,hs-CRP值越高病情越重。更多还原

【Abstract】 Objective To understand The correlation between the high sensitivity C- reactive protein( hs-CRP) and the disease course of Atherosclerotic nephropathy. Methods 40 healthy adult male Wistar rats were randomly divided into 2 groups: control group and model group,to establish the experimental model of Atherosclerotic nephropathy in rats. To detect blood lipid,renal function and hs- CRP after 0,6 and 12 weeks separately; making pathological section of aorta、renal artery and renal tissue for pathological change observation. Results The level of hs- CRP in model group was obviously higher than that in control group after 6 weeks and 12 weeks( P < 0. 05),0. 015 ± 0. 002,0. 032 ± 0. 006 respectively,the level of blood urea nitrogen( BUN) and creatinine( CREA) in model group were obviously higher than those in control group after 6 weeks and 12 weeks( P < 0. 05),and there were positive correlations between BUN and hs- CRP,CREA and hs- CRP,r is 0. 871 and 0. 940 respectively( P < 0. 05,P < 0. 01). Conclusion The hs- CRP is associated with the disease course of Atherosclerotic nephropathy,the higher the value is,the heavier the illness is.更多还原