【摘要】 目的:对比分析儿童与成人起病组的伴海马硬化的颞叶癫癎(TLE-HS)患者临床特点的异同,以提高对该病的认识。方法:回顾性收集我院癫癎诊疗中心就诊的TLE-HS患者201例,依据患者起病年龄分成儿童起病组和成人起病组,收集病史、发作类型和频率、药物治疗、头部影像学、24 h视频脑电图(V-EEG)等临床资料,作对比分析。结果:儿童起病组较成人起病组伴热性惊厥(FS)史多、间断发作少,频繁发作多,差异均有统计学意义(P=0.013、0.013、0.013);儿童起病组较成人起病组在发作间期EEG颞区以外癎样放电较多,差异有统计学意义(P=0.015)。两组患者在HS侧别、发作起源、发作类型、单用或联合用药、头部外伤史、脑炎史、家族史、精神发育迟滞、精神异常等方面比较差异均无明显统计学意义。结论:与成人起病组相比,儿童起病组伴FS史多,发作频率更高,这提示FS是导致癫癎患者更早起病的原因之一;儿童起病组发作间期EEG颞区以外癎样放电较多。更多还原

【Abstract】 Objective:To explore the characteristics in patients with temporal lobe epilepsy(TLE)with hippocampal sclerosis(HS) on children and adult onset group.and to improve the understanding of the disease.Methods:201 patients with TLE- HS were divided into 2 groups according to the age.The disease history,the types of attacks and frequency,medications,head images,24-hour video electroencephalogram(V-EEG) and other clinical data,of two groups were all analysed.Results:Children onset group had more frequents attack of febrile seizure(FS).The adult onset group had less intermittent attacks and more frequent attacks,The differences was statistically significant(P = 0.013,0.013,0.013,respectively).Children onset group had more EEG outside temporal discharge than adult onset group.The difference was statistically significant(P=0.015).In the two groups on the hippocampal sclerosis side,there were no statistical significant differences origin of seizure,seizure types,single or united medication,head trauma history,history of encephalitis,family history,mental retardation,mental disorder,etc.Conclusion:Compared with the adult onset group,children with TLE-HS have more frequent FS attack leading to more early epileptic and frequent seizure.Children onset group has more EEG outside temporal discharge than adult onset group.更多还原