【摘要】 [目的]以Sprague Dawley(SD)大鼠为试材,进行98%螺螨酯原药大鼠的生殖毒性试验。测定98%螺螨酯原药对动物繁殖和致畸方面的影响。[方法]分别通过大鼠的繁殖试验和致畸试验来确定98%螺螨酯原药对动物繁殖和致畸的影响。[结果]98%螺螨酯原药对大鼠2代繁殖试验:对大鼠系统毒性的最小有作用剂量为530 mg/kg饲料,对大鼠的生殖毒性最小有作用剂量为530 mg/kg饲料,对子代生长发育的最小有作用剂量为4 800 mg/kg饲料。98%螺螨酯原药对大鼠致畸试验:98%螺螨酯原药对母鼠的最大无作用剂量为480 mg/kg,对胎鼠的最大无作用剂量为480 mg/kg。[结论]98%螺螨酯原药对大鼠繁殖试验有一定影响,而对母鼠胚胎毒性和胎鼠生长发育没有明显影响。更多还原

【Abstract】 [Aims]Reproductive toxicity test of spirodiclofen 98%TC were conducted with Sprague Dawley(SD) rats.The study is to determine the effect of spirodiclofen 98%TC on reproductive and teratogenic action.[Methods]The effect of spirodiclofen 98%TC on reproduction and teratogenicity in rats was determined by reproductive and teratogenic test.[Results]2-Generation reproduction test on spirodiclofen 98%TC:the minimal dose of systemic toxicity in rats was 530 mg/kg diet;the minimal dose of reproductive toxicity in rats was 530 mg/kg diet;the minimal dose of offspring growth and development toxicity was 4 800 mg/kg diet.Teratogenicity test on spirodiclofen 98%TC:the NOAEL of spirodiclofen 98%TC on female rats was 480 mg/kg;the NOAEL of spirodiclofen 98%TC on fetal rats was 480 mg/kg.[Conclusions]There are some effects with spirodiclofen98%TC on reproduction in rats.But there is no significant effect on the growth and development of the embryo maternal and fetal toxicity.更多还原