【摘要】 目的:探讨卵泡抑素样蛋白1(FSTL1)在前列腺癌骨转移患者中的表达,以及血清FSTL1与机体慢性炎性因子白介素6(IL-6)、细胞生长分化调节相关因子骨形成蛋白6(BMP6)的相关性,探讨血清FSTL1对前列腺癌骨转移的临床应用价值。方法:采用ELISA法测定35例前列腺癌骨转移患者和30例良性前列腺增生(BPH)患者血清FSTL1、IL-6、BMP6水平,并进行相关性分析。结果:前列腺癌骨转移组血清FSTL1的表达水平[(20.23±8.69)μg/L]较BPH组[(35.45±12.35)μg/L]明显降低(P<0.01);血清IL-6、BMP6表达[(23.56±20.17)μg/L、(428.30±178.40)μg/L]较BPH组[(11.21±8.62)μg/L、(293.50±39.72)μg/L]明显增高(P<0.05);前列腺癌骨转移组的血清FSTL1的表达与IL-6、BMP6呈显著负相关,相关系数分别为-0.971、-0.972(P<0.05)。结论:前列腺癌骨转移患者血清FSTL1的表达降低,并且和体内炎症因子、细胞转化因子有关,为临床判断前列腺癌的发生及进展提供了新的生物学标记,为前列腺癌治疗提供了新的生物学靶向分子。更多还原

【Abstract】 Objective: To investigate the expression of follistatin-like protein 1( FSTL-1) in bone metastasis of prostate cancer( BMPC),the correlation of serum FSTL-1 with the chronic inflammatory factor interleukin-6( IL-6) and bone morphogenetic protein 6( BMP6),and the clinical application value of serum FSTL-1 in BMPC. Methods: Using ELISA,we measured the expression levels of serum FSTL-1,IL-6,and BMP6 in 35 patients with BMPC and another 30 with benign prostatic hyperplasia( BPH) and performed correlation analysis on the data obtained. Results: Compared with the BPH controls,the BMPC patients showed a significantly decreased expression of serum FSTL-1( [34. 45 ± 12. 35] μg / L vs [20. 23 ± 8. 69] μg / L,P < 0. 01) and increased levels of IL-6( [11. 21 ± 8. 62]μg/L vs [23. 56 ± 20. 12]μg/L,P < 0. 05) and BMP6( [293. 50 ± 39. 72]μg/L vs [428. 30 ± 178. 40]μg/L,P < 0. 05). There was a significant negative correlation between the level of serum FSTL-1 and those of IL-6 and BMP6 in the BMPC patients,with correlation coefficients of- 0. 971 and- 0. 972,respectively( P < 0. 05). Conclusion: The expression of serum FSTL-1 decreases in patients with bone metastasis of prostate cancer,and it is correlated with the levels of inflammatory factor and cell transformation factor. This finding offers a novel biological marker for the development and progression of prostate cancer as well as a new biological target factor for its intervention.更多还原