【摘要】 目的研究姜黄色素聚电解质纳米粒(CUR-PENPs)经大鼠尾静脉注射后的体内药代动力学。方法通过静电吸附法制备CUR-PENPs并对其表征;以姜黄色素(CUR)溶液为对照,研究大鼠尾静脉注射CUR-PENPs的体内药动学。结果透射电镜观察CUR-PENPs呈较规则类球体,平均粒径为(243.0±1.1)nm,Zeta电位为(-28.13±1.41)mV,载药量为5.5%。大鼠尾静脉注射CUR-PENPs的血药浓度-时间曲线下面积(AUC)为CUR溶液3.3倍,血浆清除率(CL)降为CUR溶液的27.8%。结论 CUR-PENPs能相对延长CUR体内滞留时间,提高药物AUC。更多还原

【Abstract】 OBJECTIVE To investigate the pharmacokinetical process of curcuminoids-loaded polyelectrolyte nanoparticles(CUR-PENPs)by i.v.administration in rats.METHODS CUR-PENPs were prepared and characterized.The rats were administrated through tail vein with curcuminoids(CUR)solution and CUR-PENPs.RESULTS CUR-PENPs were quasi-spherical shapes observed by TEM.The mean particle size,Zeta potential and drug loading were(243.0±1.1)nm,(-28.13±1.41)mV and 5.5%,respectively.After i.v.administration the area under concentration-time curve(AUC)of CUR-PENPs were 3.30-fold higher than those of CUR solution,the clearance(CL)of CUR-PENPs were 27.8%that of CUR solution.CONCLUSION The results indicate that CUR-PENPs may extend the retention time of CUR and improve the AUC when compared with CUR solution.更多还原