【摘要】 本文旨在研究黑牛肝菌多糖(RPBA)对酒精性损伤小鼠心脏及脾脏的抗氧化保护作用.将小鼠随机分为空白对照组、模型对照组、RPBA中剂量组(200 mg/kg bw·d)和高剂量组(400 mg/kg bw·d),在给予各受试样品30 d后,各组小鼠禁食不禁水12 h,然后除空白组外其余3个组都灌以50%酒精,灌胃量12 mL/kg·bw,空白对照组灌等体积的蒸馏水.12 h后将各组动物处死,取心脏、脾脏测定各项抗氧化指标.结果发现,黑牛肝菌多糖能有效提高SOD活性,降低MDA含量.结论:黑牛肝菌多糖对急性酒精损伤小鼠的心脏和脾脏有一定的保护作用.更多还原

【Abstract】 The antioxidation of refined polysaccharides from Boletus aereus( RPBA) on acute alcoholic hepatic injury of heart and spleen in mice were investigated. The mice were randomly divided into blank control group,alcoholic model control group and RPBA groups(( 200,400) mg / kg bw). All mice were administered for 30 d prior to the administration with dose of 50% alcohol( 12 mL / kg bw) except blank control group. 12 h after alcohol treament,all mice were dislocation death to assay activities of antioxidant capabilities in heart and spleen. The contents of MDA in heart and spleen revealed an obvious decrease in the RPBA treament groups when comparing to the model group,while the activity of SOD in the heart and spleen exhibited an obvious increase. Conclusions: RPBA can protect heart and spleen from injury induced by alcohol in mice.更多还原