【摘要】 目的:探讨口服普萘洛尔治疗婴幼儿血管瘤的临床疗效、安全性及方法。方法:共收治56例体表血管瘤患儿,完善检查后口服普萘洛尔治疗,初始剂量为0.5mg/kg/d,分2次餐后服用,若患儿无不良反应,则每日增加0.2mg/kg至总量1.5mg/kg/d,维持治疗4个月后每日减少0.2mg/kg至停药,治疗结束半年后参照Achauer标准进行疗效评定。结果:其中1例服药不到1个月因出现疲劳、乏力,家属放弃治疗,2例服药3个月后瘤体基本消退而停药,其余53例均维持服药4个月,治疗结束时,大部分血管瘤明显缩小,颜色变淡,甚至消退,停药6个月后评定疗效:Ⅰ级2例(含复发1例),Ⅱ级6例(含复发5例),Ⅲ级17例,Ⅳ级31例,停药后复发6例。结论:口服普萘洛尔是治疗婴幼儿血管瘤有效方法之一,其疗效及安全性可能与剂量及用药方式有关。更多还原

【Abstract】 Objective To explore the efficacy,safety and appropriate method of oral propranolol treatment for infantile hemangiomas located in superficial body. Methods 56 infants with hemangiomas in superficial body were treated from January 2010 to January 2013,including 17 males and 39 females,with age ranged from 3 to 24 months.Propranolol was administered orally twice a day after meal to all the cases after examination,which was begun with 0.5mg/kg/d,and was added 0.2mg/kg every day till it added up to 1.5mg/kg/d only if complications were not occurred in the cases,and was decreased by 0.2mg/kg every day to withdrawl when was taken at this dose for 4 months.The therapy effect after stopping treatment for six months was evaluated using Achauer system. Results53 cases took propranolol for 4 months,except that 1 case gave up therapy because of obvious fatigue during the first month of treatment,and 2 cases ended treatment as they had gotten cured almostly after taking propranolol for 3 months.Most hemangiomas decreased distinctly in size and color,and even some disappeared completely when treatment fell due.2 cases were scaleⅠ(including1 recurrence),6 cases were scale Ⅱ(including 5 recurrence),17 cases were scale Ⅲ and 31 cases were scale Ⅳ after six months of propranolol withdrawal. Conclusion Oral propranolol is one of effective methods for infantile hemangiomas,both the efficacy and safety are probably relative to its dose and usage.更多还原