【摘要】 目的:检测寻常型银屑病皮损中血管紧张素Ⅱ(AngⅡ)及血管紧张素转化酶(ACE)的水平变化。方法:应用荧光定量聚合酶链反应(FQ-PCR)和免疫组化技术检测30例寻常型银屑病患者(进行期17例,静止期13例)皮损AngⅡ和ACE mRNA及蛋白质的表达。结果:银屑病患者皮损中AngⅡ和ACE mRNA及蛋白质的表达明显高于正常人对照组(P<0.001),且进行期高于静止期(P<0.001)。结论:AngⅡ和ACE在银屑病皮损中表达上调,推测可能与银屑病皮损中新血管的形成有关。更多还原

【Abstract】 Objective:To detect the level of angiotensin Ⅱ(Ang Ⅱ) and angiotensin converting enzyme(ACE) in patients with psoriasis vulgaris.Methods:The level of Ang Ⅱ and ACE was detected by fluorescent quantitative polymerase chain reaction(FQ-PCR) and immunohistochemistry technique in 30 patients with psoriasis vulgaris(progressing stage in 17 cases and stable stage in 13) and 15 normal controls.Results:The level of Ang Ⅱ and ACE protein was significantly higher in psoriatic lesions than in controls(P<0.001) and in progressing stage higher than in stable stage(P<0.001).Conclusion:Over expression of Ang Ⅱ and ACE in psoriatic lesions may be implicated in the neovascularization of psoriasis.更多还原