【摘要】 目的探讨中老年原发性高血压患者血尿酸(UA)水平与颈动脉粥样硬化(ACS)之间的关系并分析UA对ACS的预测价值。方法随机选取单纯中老年原发性高血压患者339例。根据颈动脉内膜是否增厚及是否有斑块形成分成颈动脉粥样硬化和颈动脉正常两组,分析各组UA水平与ACS之间的关系,并分析UA对ACS发生的预测价值。结果随UA增加,ACS发生率亦增加,UA正常组ACS发生率为20.3%,高UA组ACS发生率为66.7%,差异有统计学意义(P<0.05);以UA为检测变量,ACS分组为状态变量,建立ROC曲线,其中男性曲线下面积(AUC)=0.798(P<0.05),女性AUC=0.830(P<0.05),都有较好的预测价值。结论中老年原发性高血压患者UA水平与ACS发生有关,且女性UA水平对ACS发生的预测价值更高。更多还原

【Abstract】 Objective To investigate the relationship between serum uric acid( UA) levels and the carotid atherosclerosis( ACS),and assess the predictive value of UA on ACS in middle- aged patients with essential hypertension. Method 339 cases of patients with essential hypertension were selected randomly from our high blood pressure database. All study participants were divided into two groups depending on whether carotid intimal was thickening or carotid artery block was formed,namely,ACS group and normal group. The relationship between UA levels and ACS,the predictive value of UA on ACS were analyzed. Results With the increasing of UA levels,the incidence of ACS increased rapidly,which was 20. 3% and 66. 7% in control group and ACS group,respectively( P < 0. 05). For UA test variables,the ACS group as state variables,state variables was 1,in ROC curve,UA had the largest area under the curve( AUC) of 0. 798( P < 0. 05) and 0. 830( P < 0. 05) between male and female. Conclusion The serum UA levels and ACS in related closely in the middle- aged patients with essential hypertension,and the serum UA levels of female have more higher predictive value on ACS than male.更多还原