Objective: To observe the effect of Tiaobu Drink combined with acupoint application on the spleen- kidney deficiency and the stagnation of liver qi and heart- kidney incoordination of chronic fatigue syndrome( CFS). Methods: 118 patients with CFS were randomly divided into three groups,Chinese medicine and acupoint application Group 41 cases,oral medicine group 41 cases,oral Wuling capsule group 36 cases. We observed the clinical curative effect of the three groups,and fatigue,sleep disorder and main concom...