【摘要】 目的:观察小剂量美罗华联合中药治疗难治性血小板减少性紫癜的临床疗效,探讨治疗难治性血小板减少性紫癜治疗效果的方案。方法:选择诊断为难治性特发性血小板减少性紫癜成人患者101例,随机分为对照组和观察组,对照组采用小剂量美罗华治疗,观察组则采用小剂量美罗华治疗的同时按照患者的体质采用益气、补肾、健脾、养血的方药配合治疗。治疗后第3个月时比较两组之间的治疗效果和不良反应情况。结果:观察组有效率82%,对照组有效率72%,观察组效果优于对照组(P<0.05);观察组不良反应明显少于对照组(P<0.05)。结论:小剂量美罗华联合中药治疗难治性血小板减少性紫癜疗效确切,配合中药调整可提高疗效、减少不良反应。更多还原

【Abstract】 Objective: To observe the clinical effect of small doses of rituximab combined with TCM on refractory thrombocytopenic purpura and to explore the treatment programs of refractory thrombocytopenic purpura. Methods: 101 cases of refractory idiopathic thrombocytopenic purpura patients were randomly divided into control group and observation group. The control group accepted a small dose of rituximab treatment and the observation group in accordance with the patients’ physical accepted TCM treatment on the bases of small doses of rituximab treatment. 3 months after treatment,the therapeutic effect and adverse reactions were compared between the two groups. Results: The observation group’s total effective rate was 82% and in the control group it was72%. There was significant difference( P < 0. 05). Adverse reactions in observation group was significantly less than that of the control group( P < 0. 05). Conclusion: Low-dose rituximab has a better clinical effect on refractory thrombocytopenic purpura and combination with Chinese treatment can improve the efficacy and reduce adverse reactions.更多还原