【摘要】 目的 探讨系统性红斑狼疮(SLE)患者糖皮质激素(GCs)的应用与股骨头坏死(ONFH)发生的关系。方法 回顾性分析505例SLE患者的临床资料,根据应用GCs时间分为三组:A组:未应用GCs;B组:应用GCs<3年;C组:应用GCs≥3年。与73例应用GCs治疗的肾病综合征(NS)患者进行对比分析。结果 505例SLE患者中ONFH的患病率为4.0%(20/505);A组:69例,ONFH患病率为0%;B组:327例,ONFH患病率2.4%,占ONFH的40%;C组:1 78例,ONFH患病率为6.7%,占ONFH的60%。B组和C组患病率差异有统计学意义(P<0.05)。和73例肾病综合征(NS)组患ONFH比较,差异无统计学意义(P>0.05)。结论 GCs的应用是SLE发生ONFH的主要因素。应用GCs治疗后SLE并发ONFH的几率增加。应用GCs的时间越长,出现ONFH的的几率越大。更多还原

【Abstract】 Objective To investigate whether the use of glucocorticoids in patients with SLE would correlate with femoral head necrosis.Methods 505 SLE patients were retrospectively reviewed and divided into three groups based on the time of glucocorticoids use-,group A(n=69),SLE patients is not taking glucocorticoids;group B(n=327),the time of SLE patients taking glucocorticoids is less than 3 yesrs;and group C(n=178),the time is more than or equal to 3 years.73 patients with nephritic syndrome(NS) using GCs therapy were analyzed in comparison.Results 4% of the whole 505 SLE patients happened ONFH,within them 0% ONFH patients in group one,2.4% in group two,and group three is 6.7%.The incidence of ONFH in group B differed significantly from group C(P<0.05).There were no significant differences supervene with ONFH between SLE and Nephritic syndrome(NS) who were taking GCs(P>0.05).Conclusion Glucocorticoids is more common compared SLE itself in the causative factors of ONFH.SLE patients who use glucocorticoids may be more likely happened ONFH.The longer the time,the greater the chance resulting in ONFH.更多还原