【摘要】 目的探讨成纤维生长因子受体1(FGFR1)、胰岛素样生长因子受体1(IGF1R)在肺鳞癌组织中的表达及两者的临床意义。方法采用免疫组化法检测260例肺鳞癌术后患者的癌组织及40例癌旁正常组织中FGFR1、IGF1R的表达,分析两者表达与临床病理特征及预后的关系。采用Kaplan-Meier法进行生存分析,用Cox回归模型分析影响肺鳞癌预后的独立因素。结果 FGFR1、IGF1R在肺鳞癌组织中的阳性表达率分别为51.92%(135/260)、55.4%(144/260),均明显高于癌旁正常组织的32.5%(13/40)、30.0%(12/40),差异均有统计学意义(P<0.05)。FGFR1在肺鳞癌组织中的表达与吸烟、淋巴结转移有关,IGF1R表达仅与淋巴结转移有关(P<0.005)。FGFR1、IGF1R蛋白阳性表达者的中位OS分别为38.21个月、38.48个月,均低于阴性表达者的42.55个月、42.51个月(P>0.05)。Cox多因素分析显示,FGFR1、IGF1R表达及淋巴结转移为肺鳞癌患者术后的独立预后因子。结论 FGFR1、IGF1R均参与了肺鳞癌的发生、发展,并且二者均为肺鳞癌的不良预后指标,并有望成为分子靶向治疗的新靶点。更多还原

【Abstract】 Objective To investigate the expression of fibroblast growth factor receptor 1( FGFR1),insulin-like growth factor( IGF1R) in resected squamous cell lung cancer tissue and their clinical significance. Methods The immunohistochemical method was applied to detect the protein expression of FGFR1,IGF1 R on tissue sections from 260 squamous cell lung cancer and 40 adjacent normal tissues. Then the relationship between expression of FGFR1,IGF1 R and clinicopathological characteristics and prognosis. The overall survival( OS) was estimated using the Kaplan-Meier method. The factors affecting the prognosis of squamous cell lung cancer were analyzed by Cox multivariate survival analysis. Results The positive expression rates of FGFR1,IGF1 R in squamous cell lung cancer tisssues was 32. 5%( 13 /40) and 30. 0%( 12 /40),higher than 32. 5%( 13 /40) and 30. 0%( 12 /40) of adjacent normal tissues with significant differences( P < 0. 05). FGFR1 expression was related with smoking and lymph node metastasis,and the IGF1 R expression was only related with lymph node metastasis( P < 0. 05). The median OS of patients with FGFR1 and IGF1 R positive expression was 38. 21,38. 48 months,lower than 42. 55,42. 51 months of patients with FGFR1 and IGF1 R negtive expression( P < 0. 05).Multivariate survival analysis showed that FGFR1,IGF1 R expression and lymph node metastasis may act as independent prognostic factors for squamous cell lung cancer. Conclusion Expression of FGFR1 and IGF1 R may be involved in the occurrence and development of b squamous cell lung cancer. They may serve as markers for predicting the prognosis of patients with squamous cell lung cancer.更多还原