【摘要】 糖尿病黄斑水肿(DME)是糖尿病患者眼部常见的并发症,是导致糖尿病患者视力损害的主要原因之一。其发病机制推测是视网膜内、外屏障的破坏以及各种炎症因子的作用,其中血管内皮生长因子对DME的发生发展起了至关重要的作用。随着对DME认识的加深,其治疗方法不断进步。目前DME的治疗为在严格控制血糖、血压、血脂等全身危险因素的基础上积极处理眼部并发症,主要有药物、激光光凝和手术治疗三大类。眼内注射抗血管内皮生长因子药物从其发病机制方面治疗DME,在DME的治疗中的地位越来越重要。更多还原

【Abstract】 Diabetic macular edema( DME) is a common complication of diabetes eye,and one of the major causes of visual impairment in diabetic patients. The pathogenesis of DME is presumed to be disruption of blood-retina barrier, and the effects of various inflammatory cytokines. Among these cytokines,vascular endothelial growth factor has been thought to play a crucial role in the development of DME. With the development of the knowledge about DME,several therapeutic options have been proposed. Currently,treatment for DME is based on the strict control of glucose,blood pressure, serum lipids and other risk factors. There are three main categories: medications,laser photocoagulation,and vitrectomy. Vascular endothelial growth factor inhibitors has become more and more important in the treatment of DME.更多还原