【摘要】 [目的]研究经导管肝动脉化疗栓塞术(TACE)治疗中晚期原发性肝癌的疗效并预测影响患者生存率的相关因素。[方法]80例中晚期原发性肝癌患者经1次或多次TACE治疗后,分别于治疗后第1、3、6、12个月对患者进行CT扫描评估肿瘤对治疗的反应并计算生存率。[结果]对所有患者随访观察3年(或者观察至死亡),80例患者共进行了163次TACE,按Child-pugh分级A级48例(60.0%),B级32例(40.0%);肿瘤大小<5cm 18例(22.5%),5~10cm 42例(52.5%),>10cm 20例(25.0%);行1、2、3、4次TACE的患者分别为12、56、9、3例;1、2、3年的总生存率分别为71.3%、43.8%和17.5%,肿瘤直径<5cm患者TACE后3年生存率显著高于肿瘤直径为5~≥10cm患者。[结论]TACE是治疗中晚期肝癌的一种有效的方法,能有效缓解患者的临床症状并延长生存期,初始肿瘤的大小是决定患者生存率的独立影响因素。更多还原

【Abstract】 [Objective]To investigate the outcome following transcatheter arterial chemoembolization(TACE)and to identify the predictors of survival in patients with unresetable hepatocellular carcinoma(HCC).[Methods]Eighty HCC patients get clinical,biochemical and radiological examination befrom TACE.TACE was performed in those who fulfilled the inclusion criterial follow-up assessment was done with CT scan of the liver at 1,3,6,and 12months therapeutic effect tumor response and survival rate were estimated.Univariate analyses were done for determinations of survival.[Results]eighty patients were subjected to 163sessions of TACE.The Child’s classification was:A 48patients(60%)and B 32patients(40%).Tumor size was≤5cm in 18(22.5%)patients,>5-10cm in 42(52.5%)patients,and>10cm in 20(25%)patients.12,56,9,3patients were subjected to 1,2,3,4sessions of TACE respectively,Overall survival rate was 71.3%,43.8%and 17.5%at 1,2and 3years,respectively.Tumor size energed as an important predictor of survival.Conclution:TACE offers a reasonable palliative therapy for HCC.Initial tumor size is an independent predictor of survival.更多还原