【摘要】 目的探讨乌司他丁与氨茶碱合用对脓毒症患者毛细血管渗漏指数(CLI)的影响。方法选取2013年01月~2013年12月入住ICU脓毒症患者48例,随机分为试验组和对照组,每组24例。对照组接受常规抗感染、恢复正常血容量、改善循环功能、维持足够的氧供等措施。试验组在对照组用药基础上静脉注射乌司他丁20万U,4次/d,氨茶碱500 mg,2次/d。选取治疗前、治疗后48 h 2个时间点,检测C反应蛋白及血浆白蛋白水平,计算CLI(C反应蛋白/白蛋白)值。结果与对照组相比,试验组治疗前后CLI水平无明显增高(P>0.05),而对照组有明显增高(P<0.05)。结论乌司他丁与氨茶碱合用可抑制脓毒症患者毛细血管渗漏。更多还原

【Abstract】 Objective To investigate the effect of ulinastatin combined with aminophylline on sepsis patients with capillary leak index(CLI) effect. Methods 48 cases of 2013 01 months in a 2013 December occupancy ICU sepsis patients, were randomly divided into experimental group and control group, 24 cases in each group. The control group received conventional anti infection, restored normal blood volume, improve circulation function, maintain oxygen supply measures enough. In experimental group, the control group based on the treatment of intravenous Ulinastatin 200 000 U, 4 /d, aminophylline 500 mg, 2 times / d. Select 48 hours before treatment, after treatment of 2 time points, the level of protein and plasma albumin detection of C reaction, the calculation of CLI(C reactive protein / albumin) value. Results Compared with the control group, CLI levels before and after treatment no significant increase in test group(P>0.05), while the control group were significantly increased(P<0.05). Conclusion Ulinastatin and aminophylline in patients with sepsis can inhibit capillary leakage.更多还原