【摘要】 目的探讨癌症患者输血前后TNF-α和IL-10的变化及其意义。方法选取23例癌症并贫血患者,用ELISA法分别测定患者输血(输乏白细胞红细胞)前1 d和输血后第1天和第5天的血清TNF-α和IL-10的含量。结果输血前1 d、输血后第1天和输血后第5天血清TNF-α含量分别为(1.42±0.48)、(2.55±0.84)和(5.11±1.22)μg·L-1,IL-10含量分别为(6.86±1.09)、(9.93±1.48)和(9.83±1.30)μg·L-1。TNF-α含量输血前1 d、输血后第1天和输血后第5天比较差异有统计学意义(均P<0.01);IL-10含量输血前1 d、输血后第1天比较差异有统计学意义(P<0.01)。结论癌症患者输乏白细胞红细胞后仍然存在免疫抑制现象,加强输血风险评估对临床有一定的帮助。更多还原

【Abstract】 Objective To investigate the changes in TNF-α and IL-10 before and after leukocytedepleted blood transfusions in cancer patients and their clinical significance. Methods The serum concentrations of TNF-α and IL-10 were measured by ELISA on the day before leukocyte-depleted blood transfusions and on the first and fifth days after blood transfusions in 16 cancer patients with anemia. Results The concentrations of TNF-α and IL-10 were, respectively,(1.42 ±0.48)μg·L-1and(6.86±1.09)μg·L-1on the day before blood transfusions,(2.55±0.84)μg·L-1and(9.93±1.48)μg·L-1on the first day after blood transfusions, and(5.11±1.22)μg·L-1and(9.83±1.30)μg·L-1on the fifth day after blood transfusions. The differences in TNF-α concentrations were significant among the three days(P<0.01).The differences in IL-10 concentrations were significant between the day before blood transfusions and the first day after blood transfusions(P <0.01). Conclusion The immunosuppression is present in cancer patients transfused with leukocyte-depleted blood. The enhancement of risk assessment can provide appropriate assistance for clinical blood transfusions.更多还原