【摘要】 目的 探讨佐匹克隆与奥沙西泮治疗失眠症患者的临床疗效和安全性。方法 将100例失眠症患者随机分为研究组51例,对照组49例,研究组口服佐匹克隆治疗,对照组口服奥沙西泮治疗,观察4周。于治疗前后采用睡眠障碍评定量表评定临床疗效,副反应量表评定不良反应。结果 治疗4周末,研究组显效率86.3%、总有效率96.1%,对照组分别为77.6%、93.9%,两组临床疗效比较差异无显著性(x~2=1.31,P>0.05)。研究组不良反应发生率为9.8%,对照组为42.8%,研究组显著低于对照组(x~2=14.19,P<0.01)。结论 佐匹克隆与奥沙西泮治疗失眠症疗效显著,总体疗效相当,但佐匹克隆安全性更高,依从性更好,更适用于初次就诊的失眠症患者。更多还原

【Abstract】 Objective To explore the efficacy and safety of zopiclone and oxazepam in the treatment of insomnia.Methods A total of 100 insomnia patients were randomly divided into research（>i = 51） and control group（n=49）.research took orally zopiclone and control group did oxazepam for 4 weeks.Efficacies were assessed with the Sleep Dysfuntion Rating Scale（SDRS） before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale（TESS）.Results At the end of the 4^th week obvious and total effective rate were respectively 86.3%and 96.15 in research and 77.6%and 93.9%in control group,which showed no significant differences（x²= 1.31.P>0.05）.The rate of adverse reactions was 9.8%in research and 12.8%in control group,the former was significantly lower than the latter（x²=14.19,P<0.01）.Conclusion Both zopiclone and oxazepam have an evident and equivalent effect in insomnia.hut the former has higher safety and hetter compliance and is more suitable for first visiting insomnia patients.更多还原