【摘要】 目的 探讨乌司他丁对糖尿病肾脏疾病(diabetic kidney disease,DKD)患者冠状动脉造影术后的肾脏保护作用。方法 募集因反复心绞痛需行冠状动脉造影术的DKD患者43例,随机分为治疗组(n=23)和对照组(n=20)。从造影前12 h至造影后12 h,2组均用0.9%氯化钠注射液静脉滴注水化,不同之处为治疗组自造影当天开始每日静滴乌司他丁20万单位,而对照组仅静滴0.9%氯化钠注射液100 ml,疗程均为7 d。分别于造影前及造影后1、3、7 d留取2组患者的外周血标本,利用生化仪检测2组患者血肌酐(SCr)及血胱抑素C(Cys C)水平。结果 ①2组患者冠状动脉造影术后其外周血中SCr及CysC的值均升高;②治疗组患者外周血中SCr及CysC于第3天及第7天升高幅度显著低于对照组(P<0.05),且差异有统计学意义。结论 乌司他丁能降低DKD患者行冠状动脉造影术后SCr及CysC升高幅度,具有肾脏保护作用。更多还原

【Abstract】 Objective To investigate the renal protective effects of ulinastatin in diabetic kidney disease patients after coronary angiography.Methods Forty-three cases of diabetic nephropathy were divided randomly into two groups:experimental group(n = 23) and control group(n = 20).All patients were subjected to coronary angiography because of intractable angina.The patients in both two groups were intravenously dripped with normal saline for hydration from 12 h before coronary angiography to 12 h after coronary angiography.The experimental group was given ulinastatin of 2.0×10~5 U every day after coronary angiography,and the control group was given normal saline.Treatment period was 7 days.The serum creatinine(SCr) and cystatin C(Cys C) levels were determined before and at day 1,3 and 7 after coronary angiography.Results(1) SCr and Cys C levels in two groups were both increased after coronary angiography;(1) The increased extent of SCr and Cys C in experiment group was significantly lower than in control group(P<0.05).Conclusions Ulinastatin can more effectively decrease levels of SCr and Cys C in diabetic kidney disease patients after coronary angiography and play the role of protecting the kidney.更多还原