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特应性斑贴试验方法学的英文文献分析
Literature analysis of methodology of atopic patch test
【摘要】 目的:分析特应性斑贴试验(atopic patch test,APT)应用现状,强调其临床价值。方法:整理有关APT方法学的英文文献114篇,对疾病种类、变应原、阳性率、灵敏度、特异度、阳性预测值、阴性预测值、受试部位、斑试器选择、封闭时间、判读时间、判读标准和试验前皮肤处理情况进行统计。结果:APT主要用于特应性皮炎(atopic dermatitis,AD)的诊断,所有统计文献涉及APT诊断AD的共84篇,占统计文献的73.7%;APT食物变应原中牛奶、鸡蛋、小麦、大豆最常见,涉及的文献分别占统计文献的45.6%,38.6%,29.8%和20.2%。各种变应原对应的特异度、阳性预测值及阴性预测值均较高,而阳性率、灵敏度、变异度较大。多数文献选择背部作为受试部位,变应原置于12mm芬兰小室,敷贴48 h,根据欧洲特应性皮炎工作小组(ETFAD)标准判读。结论:APT、在食入及吸入性过敏原相关疾病的诊断中具有较高的临床价值,但目前应用比较混乱,仍需不断实践推广其应用价值。
【Abstract】 Objective:To analyze the application status of atopic patch test (APT) and emphasize its clinical value.Methods:All Enghsh literatures refer to the methodology of APT were reviewed,the disease categories,allergens,positive rate,sensitivity,specificity,positive predictive value,negative predictive value,test site,test chambers,occlusion time,reading time,reading criteria and skin abrasion were calculated.Results:APT was mainly used to diagnose atopic dermatitis (AD),84 literatures referred to APT as a diagnostic method for AD,accounted for 73.3% in all literatures.Milk,egg,wheat and soy,which accounted for 45.6%,38.6%,29.8% and 20.2% respectively in all accounted papers,were most common in all food allergens.The specificity,positive predictive value and negative predictive value of each food were high,but with various positive rate and sensitivity.Back was chose to be the test site in most literature,the allergens were placed in 12 mm Finn chambers for 48 h application,reading according to ETFAD criterion.Conclusions:APT has a high clinical value on the diagnosis of food and aeroallergens-related diseases,but with a disorderly application,which needs a constant practice to popularize its application value.
- 【文献出处】 临床皮肤科杂志 ,Journal of Clinical Dermatology , 编辑部邮箱 ,2014年07期
- 【分类号】R758.2
- 【被引频次】3
- 【下载频次】91