【摘要】 目的观察硫酸镁对妇科手术患者腰-硬联合麻醉中布比卡因蛛网膜下腔运动阻滞半数有效剂量(ED50)的影响。方法择期行妇科手术患者88例,随机分为两组。两组均采用腰-硬联合麻醉,分别在蛛网膜下腔阻滞后静脉注射硫酸镁25mg/kg(M组)或等量生理盐水20ml(C组)。采用序贯法进行试验,布比卡因剂量从6mg开始,运动阻滞达到Bromage 3分则下一例的剂量减少1mg,反之则增加1mg,Dixon-Mood法计算布比卡因ED50及其95%可信区间(CI)。结果 C组布比卡因蛛网膜下腔阻滞运动阻滞ED50为7.827(95%CI 7.341~8.345)mg,M组ED50为7.014(95%CI 6.618~7.434)mg,M组明显低于C组(P<0.05)。结论单次静脉注射硫酸镁25mg/kg可以明显降低布比卡因蛛网膜下腔运动阻滞的ED50。更多还原

【Abstract】 Objective To investigate the effect of a single intravenous injection of magnesium sulfate on the median effective dose(ED50)of intrathecal bupivacaine in patients undergoing gynecological surgery.Methods Eighty-eight ASA ⅠorⅡ patients for elective gynecological surgery were enrolled in this double-blind,randomized study under combined spinal epidural anesthesia.These patients were randomly assigned to one of the following two groups.Group M(n=44)received intravenous injection of 25mg/kg MgSO4,and group C(n=44)received the same volume of saline.The ED50 was determined by an up-and-down sequential method.The initial dose of bupivacaine of 6mg. If satisfactory motor block was obtained(Bromage score=3),the dose in the next case would be decreased 1mg,or otherwise,increase 1 mg.Dixon-Mood method was used to calculate the ED50. Results The ED50of intrathecal bupivacaine was 7.827mg(95%CI 7.341-8.345mg)in group C and 7.014mg(95%CI 6.618-7.434mg)in group M.The ED50in group M was significantly lower than in group C(P<0.05).Conclusion A single intravenous injection of 25mg/kg MgSO4could decrease the median effective dose of intrathecal bupivacaine.更多还原