【摘要】 目的观察短暂性脑缺血发作(TIA)患者血清氧化低密度脂蛋白(ox-LDL)水平及其与ABCD2评分间的关系。方法选取82例TIA患者和55例健康对照者;根据ABCD2评分,将TIA患者分为高危亚组(ABCD2>3,n=39)和低危亚组(ABCD2≤3,n=43)。分别检测两组TIA患者和健康对照者血清ox-LDL水平,同时分析其血脂、清蛋白(Alb)及高半胱氨酸(Hcy)水平,并进行统计学分析。结果与健康人对照组比较,TIA患者血清ox-LDL及三酰甘油、游离脂肪酸、Hcy水平均升高(F分别为15.97、11.85、8.22、和18.56,P均<0.001),高密度脂蛋白胆固醇、Alb水平均降低(F分别为21.27、15.39,P均<0.001)。TIA患者中,高危亚组ox-LDL水平高于低危亚组(t值为2.39,P=0.02)。多因素Logistic回归分析显示,在校正了年龄、性别、其他血脂指标及Alb水平的影响后,高ox-LDL、Hcy水平是TIA的危险指标(高危亚组:ox-LDL,风险比(OR)=1.17,95%可信区间(CI)=1.06~1.30;Hcy,OR=1.77,95%CI=1.04~2.96;低危亚组:ox-LDL,OR=1.10,95%CI=1.01~1.21;Hcy,OR=1.65,95%CI:1.01~2.70);且ox-LDL对两组TIA患者的鉴别仍具有意义(OR=1.06,95%CI:1.00~1.13)。结论 TIA患者血清ox-LDL水平升高,与ABCD2评分密切相关。更多还原

【Abstract】 Objective To detect the levels of serum oxidized low-density lipoprotein( ox-LDL) in patients with transient ischemica attack( TIA),and evaluate its correlation with ABCD2 score. Methods Eighty-two TIA patients and 55 healthy controls were enrolled in the study. According to ABCD2 scores,TIA patients were divided into two groups,the high-risk group with ABCD2 score > 3( n =39) and the low-risk group with ABCD2 score≤3( n = 43). Serum ox-LDL,homocysteine( Hcy),lipid and albumin levels in TIA patients and healthy controls were determined and analyzed. Results Compared with healthy controls,serum ox-LDL,triglycerides,free fatty acid and Hcy levels in TIA patients increased significantly( F-value = 15. 97,11. 85,8. 22 and 18. 56,respectively,P < 0. 001),while high-density lipoprotein cholesterol and albumin levels decreased obviously( F-value = 21. 27 and 15. 39,P < 0. 001). In TIA patients,the ox-LDL levels in the high-risk group were significantly higher than that in the low-risk group( t = 2. 39,P = 0. 02). The multiple Logistic regression analysis showed that,after adjusting for age,gender,serum lipid and albumin levels,serum ox-LDL and Hcy levels were the risk factors of TIA( high-risk group: ox-LDL,OR = 1. 17,95% CI = 1. 06-1. 30; Hcy,OR = 1. 77,95% CI =1. 04-2. 96; low-risk group: ox-LDL,OR = 1. 10,95% CI = 1. 01-1. 21; Hcy,OR = 1. 65,95% CI = 1. 01-2. 70). Moreover,ox-LDL was able to differentiate the high risk and low risk of TIA( OR = 1. 06,95% CI = 1. 00-1. 13). Conclusion Increase of serum ox-LDL levels in TIA patients is closely related to ABCD2 score.更多还原