【摘要】 目的:探讨首发和复发抑郁症患者执行功能损害情况。方法:采用威斯康星卡片分类测验(WCST)、Stroop测验、汉密尔顿抑郁量表(HAMD-17)对100例抑郁症患者进行评定,其中首次发病(首发组)患者41例,复发(复发组)患者59例;同时以50名正常人作为对照组进行测评并分析比较。结果:在WSCT的总错误数、分类完成数、持续性错误数及持续性应答数、以及Stroop色词测验的彩色文字阅读(Stroop-c)时间和彩色文字的色彩阅读(Stroop-cw)正确数上,首发组、复发组与对照组之间差异均有统计学意义(P<0.05或P<0.01);Stroop-c正确数上首发组和复发组之间差异无统计学意义(P>0.05)。结论:无论首发还是复发抑郁症患者均存在明显的执行功能损害,复发者更为显著。更多还原

【Abstract】 Objective: To explore the impairment of executive function between patients with first-episode and recurrent depression. Method: The Wisconsin card sorting test( WCST),Stroop test,Hamilton depression scale( HAMD-17) were used to evaluate 100 depressive patients,in which the first onset patients( first-episode group) 41 cases,recurrence patients( recurrent group) 59 cases. The results were compared with50 normal controls. Results: There were statistically significant difference among the first-episode group,the recurrent group and the control group( P < 0. 05 or P < 0. 01) on the total number of errors,classification number,perseverative errors,sustained responders of the WCST,time of Stroop-c and correct number of Stroop-cw,but no statistically significant difference on the Stroop-c correct number between the first episode group and the recurrent group( P > 0. 05). Conclusion: There are significant impairment of executive function in patients with first-episode and recurrent depression,which in recurrent depression patients are more obvious impairment.更多还原