【摘要】 目的:探讨首次发病住院苯丙胺类兴奋剂(ATS)所致精神障碍患者的认知功能特点及其影响因素。方法:采用韦氏记忆量表(WMS-RC)、连续操作测验(CPT)、威斯康星卡片分类测验(WCST)评定80例首发ATS所致精神障碍患者(研究组)和80名健康人(对照组)的认知功能;采用简明精神病量表(BPRS)评定患者病情严重程度。对影响神经心理学测验成绩与BPRS进行逐步多元回归分析。结果:研究组WCST中的总应答数、持续错误数、随机错误数显著高于对照组(F=10.87～68.78,P<0.01或P<0.001);正确应答数、完成分类数、记忆商数、数字累加、短时记忆、瞬时记忆、连续操作测验正确数均显著低于对照组(F=4.92～114.20,P<0.05或P<0.001)。研究组总应答数和持续错误数与BPRS总分呈正相关(β=0.26,P=0.01;β=0.20,P=0.02);随机错误数与敌对猜疑分呈正相关(β=0.23,P=0.02);正确应答数与思维障碍分呈负相关(β=-0.25,P=0.01);完成分类数与缺乏活力分呈负相关(β=-0.25;P=0.01);记忆商数和长时记忆与焦虑忧郁分呈负相关(β=-0.32,P=0.00;β=-0.25,P=0.00);短时记忆和瞬时记忆与缺乏活力分呈负相关(β=-0.36,P=0.00;β=-0.32,P=0.00);CPT正确数与BPRS总分呈负相关(β=-0.34,P=0.00)。结论:首发ATS所致精神障碍患者的记忆、注意和执行功能等明显减退,临床症状严重程度越大,认知功能损害越大。更多还原

【Abstract】 Objective: To explore the cognition function features and the affecting factors in patients with first-episode mental disorders caused by amphetamine-type stimulants(ATS).Method: Eighty mental disorder patients caused by ATS(study group)and 80 healthy controls(control group)were involved.The cognitive function was measured with a series of neuropsychological test,and the illness severity assessed with the brief psychiatric rating scale(BPRS).Results: The scores of total responses,preservative errors,random errors in WCST in research group were higher than those in control group(F=10.87- 68.78; P<0.01 or P<0.001).However,the scores of correct responses,number of categories completed,memory quotient,numeric accumulation,short-term and instantaneous memory,continuous performance test(CPT)correct number were significantly lower than those in control group(F=4.92- 114.20; P<0.05 or P<0.001).The research group total responses and preservative errors were positively correlated to the BPRS total score(β=0.26,P=0.01; β=0.20,P=0.02),random errors were positively correlated to hostile suspicion score(β=0.23,P=0.02),correct responses were negatively correlated to thought disorder score(β=- 0.25,P=0.01),number of categories completed were negatively correlated to lack of energy score(β=- 0.25,P=0.01),memory quotient and long-term memory were negatively correlated to anxiety depression score(β=- 0.32,P=0.00; β=- 0.25,P=0.00),short-term and instantaneous memories were negatively correlated to lack of energy score(β=- 0.36,P=0.00; β=- 0.32,P=0.00),CPT correct number was negatively correlated to BPRS total score(β=- 0.34,P=0.00).Conclusion: The paitents with first-episode mental disorders caused by ATS have obvious impairments in memory,attention and execute function.The more severe the clinical symptoms is,the greater the impairment on the cognitive function is.更多还原