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慢性乙型肝炎患者血清脂联素水平及其与代谢指标的关系
Relationship between serum adiponectin level and metabolic indices in patients with chronic hepatitis B
【摘要】 目的探讨慢性乙型肝炎(CHB)和CHB合并脂肪肝患者血清脂联素(ADP)变化及与体脂、血脂、胰岛素抵抗(IR)的关系。方法选择CHB和CHB合并脂肪肝患者各20例,健康对照组18例,3组年龄、性别比较差异无统计学意义。测量其空腹体质量、腰围(WC)和臀围,检测血清胰岛素(FINS)、糖(FBG)、血脂和ALT、AST等,计算身体质量指数(BMI)、腰臀比(WHR)和胰岛素抵抗指数(HOMA-IR);采用ELISA法测定血清ADP浓度。计量资料采用均数±标准差(x±s)表示,组间比较采用单因素方差分析,计数资料组间比较采用卡方检验,相关性分析用Pearson相关分析。结果 CHB患者ADP质量浓度为(10.56±2.48)mg/L,CHB合并脂肪肝患者为(4.46±2.16)mg/L,对照组为(6.38±2.91)mg/L,3组差异有统计学意义(F=30.537,P=0.000)。CHB合并脂肪肝患者的BMI、WC、WHR及血清三酰甘油(TG)均明显高于CHB组和对照组(P均<0.01);3组血清FINS、FBG、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及IR差异均无统计学意义。所有CHB患者ADP与BMI、WC、WHR、IR、FINS、FBG、TC、HDL-C及LDL-C均无相关性,仅在合并脂肪肝时与TG呈负相关(r=-0.485,P=0.015)。结论 CHB患者血清ADP水平明显升高,推测可能是ADP对肝脏产生保护作用的反应,而在合并脂肪肝时明显降低,与TG升高关系密切。
【Abstract】 Objective To investigate the relationship of serum adiponectin level with body fat,blood lipids,and insulin resistance(IR) in the patients with chronic hepatitis B(CHB) and patients with CHB and fatty liver.Methods Twenty patients CHB,20 cases of CHB with fatty liver,and 18 healthy controls were included in the study;there were no significant differences in sex and age between the three groups.Fasting body weight,waist circumference(WC),hip circumference(HC),fasting insulin(FINS),fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),high- density lipoprotein cholesterol(HDL- C),low- density lipoprotein cholesterol(LDL- C),alanine aminotransferase(ALT),and aspartate aminotransferase(AST) were measured,and body mass index(BMI),waist- to- hip ratio(WHR),and homeostasis model assessment of insulin resistance were calculated.Serum concentrations of adiponectin were determined by enzyme- linked immunosorbent assay.Continuous data was expressed as x ± s,and comparisons between groups were made by one- way analysis of variance;comparisons of categorical data between groups were made by R × C χ2test;correlation analysis was performed by Pearson correlation test.Results The serum adiponectin concentrations of patients with CHB,patients with CHB and fatty liver,and healthy controls were 10.56 ± 2.48,4.46 ± 2.16,and 6.38 ± 2.91 mg / L,respectively,with significant differences between the three groups(F = 30.537,P = 0.000).The patients with CHB and fatty liver had significantly higher BMI,WC,WHR,and serum TG level than the CHB patients and healthy controls(P < 0.01);there were no significant differences in serum FINS,FBG,TC,HDL- C,LDL- C,and IR values between the three groups.Serum adiponectin level was only negatively correlated with TG in patients with CHB and fatty liver(r =- 0.485,P = 0.015),but not correlated with BMI,WC,WHR,IR,FINS,FBG,TC,HDL- C,and LDL- C in all patients with CHB.Conclusion Serum adiponectin level significantly increases in the patients with CHB,which may presumably be the result of adiponectin exerting a protective effect on the liver,while it significantly decreases in the patients with CHB and fatty liver,which is closely related to elevated TG.
- 【文献出处】 临床肝胆病杂志 ,Journal of Clinical Hepatology , 编辑部邮箱 ,2014年04期
- 【分类号】R512.62
- 【被引频次】5
- 【下载频次】55