目的探讨脐血与健康供者稳态骨髓中血管内皮生长因子(VEGF)、转化生长因子β1(TGF-β1)、Tie-2、血管生成素(Ang-1、Ang-2)的血浆浓度变化。方法采用酶联免疫吸附测定(ELISA)方法对32例脐血和健康供者稳态骨髓的VEGF、TGF-β1、Tie-2、Ang-1及Ang-2的血浆浓度进行检测。结果脐血中VEGF的水平与稳态骨髓比较显著升高446.62(44.31~1 430.46)ng/L vs 131.62(16.62~1 201.92)ng/L(P<0.01)。脐血中TGF-β1的水平与稳态骨髓比较却显著减低276.36(80.91~880.91)ng/L vs 476.36(235.45~1 390.00)ng/L(P<0.01)。稳态骨髓中Tie-2的血浆浓度与脐血比较差异无统计学意义(P>0.05)。尽管骨髓中Ang-1、Ang-2的浓度与脐血相比,有增加的趋势,但是差异均无统计学意义(P>0.05)。结论脐血和稳态骨髓中VEGF和TGF-β1水平的差异提示脐血和骨髓造血干细胞所处的微环境可能不同。
【英文摘要】
Objective To explore the alteration of vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),Tie-2,angiopoietins(Ang-1,Ang-2)in umbilical cord blood(UCB)and bone marrow(BM). Methods Using ELISA method,the plasma levels of TGF-β1,VEGF,Tie-2,Ang-1and Ang-2were detected in 32UCB and BM donors.Results The plasma level of VEGF in UCB was significantly higher than in BM,446.62(44.31-1 430.46)ng/L vs 131.62(16.62-1 201.92)ng/L(P <0.01).The plasma level of TGF-β1 in UCB was significantly lo...