【摘要】 以(S)-2-氨基丁酰胺、衣康酸二甲酯为起始原料经环合、还原、磺酰化、取代、还原、取代六步反应得到(s)-2-N-[4-(2-溴乙酰基)胺基乙基-2-氧基吡咯烷酮]丁酰胺。反应总收率为10.7%。目标化合物的结构经MS,1H-NMR确证。该化合物合成难度大,工艺需进一步优化。更多还原

【Abstract】 The substance which is an important medicine intermediate of antiepileptic drugs was obtained from( S)-2-aminobutanamide and dimethylitaconate via cycloaddition,reduction,sulfonylation,substitution,reduction,substitution six reactions. The total yields of six reactions was 10. 7%. The structure of them were confirmed by element analysis,MS,1H-NMR. The synthetic route for medicine intermediate is great diffculty. The synthetic technics is further optimized.更多还原