【摘要】 目的研究氧化锆种植体材料及新涂层处理方法对骨结合的影响,为该种植体系统开发及应用提供依据。方法选择未加涂层的氧化锆试件、10%多孔涂层氧化锆试件,分别将其植入健康成年雄性新西兰白兔股骨区,每侧股骨各植入2枚试件(分别为未加涂层和有涂层试件)(长度10 mm,直径2 mm)。采用推出实验评测试件-骨结合的程度,扫描电镜观察试件-骨之间的界面及其成分。结果 4周(t=103.345,P<0.001)、12周(t=24.251,P<0.001)、26周(t=20.854,P<0.001)推出实验结果两组间均有统计学差异。扫描电镜结果显示试件与骨形成较好骨结合,并观察到经过表面处理的试件表面与骨组织间有类似"骨突"样结构。结论氧化锆种植体材料在实验动物体内能够获得稳定的骨结合,多孔涂层处理方法有助于促进骨结合形成。更多还原

【Abstract】 Objective To investigate the influence of new zirconia implant and surface modified method on the osseointegration to provide evidence for the development and application of the implant. Methods Healthy adult New Zealand White male rabbits received two types of implant with identical geometry on the femur: sintered zironcia implant for NO. 1,zirconia implant with 10% porous coating for NO. 2. Each animal received two types of implant and then healed for three time periods( 4,12 and 26 weeks). At each healing time,a push-out test was performed to assess implants stability,while scanning electron microscopy analysis( SEM) was performed to scan the bone-implant interface. Results Two independent samples t test analysis revealed that there were statistical differences between the two groups at each healing period( 4 week t = 103. 345,P < 0. 001; 12 week t = 24. 251,P < 0. 001; 26 week t = 20. 854,P <0. 001). Remarkable osseointegration was seen with sintered zironcia implant and 10% porous coating zironcia implant. Conclusions The new zirconia implant and surface modified method can enhance the osseointegration.更多还原