【摘要】 目的系统评价国内腮腺术后植入异种脱细胞真皮基质预防Frey’s综合征发生的效果。方法全面检索中国期刊全文数据库、中国生物医学期刊引文数据库、中文科技期刊数据库、万方数据库、中国生物医学文献数据库中有关异种脱细胞真皮基质在腮腺术后预防Frey’s综合征的随机/半随机对照试验和临床对照试验,2名研究者独立提取资料和质量评估,最后采用RevMan5.1软件对资料进行Meta分析。结果最终纳入20个研究,共1 742例受试者,meta分析结果显示腮腺术后植入异种脱细胞真皮基质能降低发生Frey’s综合征的风险,从患者主观方面和碘淀粉试验客观评价其均有统计学意义[RR=0.12,95%CI(0.08,0.18);RR=0.15,95%CI(0.12,0.19),P<0.000 01]。结论腮腺手术后,植入异种脱细胞真皮基质可以有效降低Frey’s综合征的发生率,安全性好,但仍需要多样本、高质量、长期随访的随机对照试验以提供更可靠的证据。更多还原

【Abstract】 Objective To detect the effect of acellular dermal matrix for the prevention of Frey’s syndrome after domestic parotidectomy. Methods The CNKI、CMCI、VIP、CBM、Wangfang databases were searched electronically. The randomized /semi-randomized controlled trials and cntrolled clinical trials concerning acellular dermal matrix for preventing Frey’s syndrome after parotidectomy were included for meta-analysis. The risk of bias assessment was performed using Cochrane Collaboration’s tool and data extraction was independently performed by 2 reviewers. The meta-analysis was performed with Review Manager,version 5. 1. Results 20 randomized clinical trials including 1,742 participants were included. The meta-analysis results showed that implantation of acellular dermis matrix can reduce the risk of Frey’s syndrome by subjective assessment( relative risk [RR]= 0. 12,95% confidence interval [CI]0. 08 to 0. 18;P < 0. 000 01) The acellular dermis matrix can reduce the risk of Frey’s syndrome by objective assessment through starch iodine test( RR =0.15,95% CI 0.12 to 0.19; P <0.000 01). Conclusions The present clinical evidence suggests that acellular dermis matrix is effective in preventing Frey’s syndrome after parotidectomy,but more qualified multi-sample randomized controlled trials with longterm reviews are required to provide better basis.更多还原