【摘要】 目的探讨血清及脑脊液的γ-干扰素(INF-γ)水平对结核性脑膜炎诊断的临床价值。方法采用酶联免疫吸附试验(ELISA)检测25例结核性脑膜炎(结核性脑膜炎组)、31例病毒性脑膜炎(病毒性脑膜炎组)、12例化脓性脑膜炎(化脓性脑膜炎组)患者血清及脑脊液中INF-γ水平。结果结核性脑膜炎组患者脑脊液INF-γ含量为(386.3±83.5)ng/L,明显高于病毒性脑膜炎组(63.4±16.2)ng/L和化脓性脑膜炎组(116.8±22.6)ng/L,差异有统计学意义(P<0.01),且重叠性很小;而3组血清INF-γ含量很低并相近,差异无统计学意义(P>0.05)。脑脊液INF-γ诊断结核性脑膜炎的灵敏度、特异度和准确度分别为92.0%、95.3%和94.1%。结论检测脑脊液INF-γ对结核性脑膜炎有一定的辅助诊断价值。更多还原

【Abstract】 Objective To evaluate the clinical utility of interferon-gamma(IFN-γ)in serum and cerebrospinal fluid in the diagnosis of tuberculous meningitis.Methods IFN-γlevels in serum and cerebrospinal fluid were analyzed by ELISA method in25 patients with tuberculous meningitis,31 patients with viral meningitis and 12 patients with suppurative meningitis.Results The IFN-γlevels in cerebrospinal fluid were significantly higher in the patients with tuberculous meningitis(386.3 ± 83.5)ng/L than in the patients with viral meningitis(63.4 ± 16.2)ng/L or the patients with suppurative meningitis(116.8 ±22.6)ng/L(P<0.01).The overlap was very small.In contrast,the serum IFN-γlevels were very similar among the three groups(P>0.05).The sensitivity,specificity and accuracy of IFN-γlevel in cerebrospinal fluid for diagnosis of tuberculous meningitis were 92.0%,95.3%and 94.1%,respectively.Conclusions Measurement of IFN-γlevel in cerebrospinal fluid may be helpful for the diagnosis of tuberculous meningitis.更多还原