【摘要】 目的比较急性心肌梗死(AMI)和慢性稳定型心绞痛(CSA)患者血清α-Klotho蛋白浓度的差异。方法选择拟诊冠心病(CAD)准备行冠状动脉造影(CAG)的患者为研究对象。入院24 h内采集病史、生化数据、血清α-Klotho蛋白浓度。应用单因素、多因素分析急性心肌梗死组(n=84)与慢性稳定型心绞痛组(n=90)血清α-Klotho蛋白浓度的差异。结果急性心肌梗死组血清α-Klotho浓度低于慢性稳定型心绞痛组(903.19±558.13ng/L比1075.10±535.29 ng/L),组间差异有统计学意义(P<0.05)。Logistic回归分析显示,校正性别、年龄、吸烟史、饮酒史、早发冠心病家族史、高血压病病史、总胆固醇(TC)、高密度脂蛋白(HDLC)、肌酐清除率、2型糖尿病病史后,血清α-Klotho蛋白浓度与急性心肌梗死呈负相关(OR=0.995,95%CI为0.993~0.997,P<0.05)。结论慢性稳定型心绞痛患者血清α-Klotho蛋白浓度高于急性心肌梗死患者。血清α-Klotho蛋白浓度与急性心肌梗死呈负相关。更多还原

【Abstract】 Aim To compare the difference of serum α-Klotho protein concentration in patients between acute myocardial infarction and chronic stable angina pectoris. Methods Patients who suffered coronary heart disease and treated by coronary angiography were selected as the research object. Within 24 hours after the patients were hospitalized, their medical history,physiological and chemical data and serum α-Klotho protein concentration were collected. Univariate analysis method and multivariate analysis method were used to analyze the difference of serum α-Klotho protein concentration in acute myocardial infarction group( n = 84) and chronic stable angina pectoris group( n = 90). Results The serum α-Klotho protein concentration in acute myocardial infarction group was lower than that in chronic stable angina pectoris group( 903. 19 ± 558. 13 ng / L vs 1075. 10 ± 535. 29 ng / L),and the difference was statistically significant( P < 0. 05). Logistic regression analysis showed that gender,age,smoking history,drinking history,family history of early onset coronary heart disease,hypertension history,total cholesterol,high density lipoprotein cholesterol,creatinine clearance,and type 2 diabetes mellitus history were adjusted,serum α-Klotho protein concentration was negatively correlated with acute myocardial infarction( OR = 0. 995,95% CI was 0. 993 ~ 0. 997,P < 0. 05). Conclusions Serum α-Klotho protein concentration in chronic stable angina pectoris group was higher than that in acute myocardial infarction group. The serum α-Klotho protein concentration was negatively correlated with acute myocardial infarction.更多还原