【摘要】 目的分析七叶皂苷钠联合依达拉奉治疗脑出血患者的效果。方法将梁平县人民医院2009年1月至2013年6月神经内科收治的120例脑出血患者按治疗方法不同分为观察组和对照组,每组各60例。对照组患者采用常规保守疗法,观察组在常规治疗的基础上采用七叶皂苷钠联合依达拉奉治疗,比较两组患者治疗14d后与治疗前脑水肿体积、美国国立卫生院卒中量化表(NIHSS)评分、Barthel指数(BI)评分变化,比较治疗7d后与治疗前血清氧化亚氮(NO)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)水平差值。结果观察组患者治疗后脑水肿体积、NIHSS评分、BI评分及血清NO、TNF-α、IL-6水平与治疗前的差值分别为(4.75±2.21)mL、(6.25±2.21)分、(35.29±21.79)分、(4.33±1.15)pg/mL、(4.64±1.73)pg/mL、(8.33±4.17)pg/mL;对照组治疗后脑水肿体积、NIHSS评分、BI评分及血清NO、TNF-α、IL-6水平与治疗前的差值分别为(7.11±3.09)mL、(7.85±2.69)分、(32.87±20.34)分、(8.02±4.54)pg/mL、(5.76±2.78)pg/mL、(20.11±10.29)pg/mL,两组比较差异均有统计学意义(P<0.05)。结论七叶皂苷钠联合依达拉奉治疗急性脑出血效果明显,值得临床推广应用。更多还原

【Abstract】 Objective To analyze the effect of sodium aescinate combined with edaravone in treating cerebral hemorrhage.Methods 120 cases of cerebral hemorrhage in the neurology department of the Liangping County People’s Hospital from January 2009 to June 2013 were divided into the observation group and the control group according the therapeutic methods,60 cases in each group.The control group used the conventional conservative treatment,while on this basis the observation group adopted the treatment of aescinate combined with edaravone.The changes of cerebral edema volume,NIH stroke score and Barthel index(BI)score were compared between before treatment and after 14 d treatment.The differences of the serum NO,TNF-α,IL-6 levels also were compared between before treatment and after 7 d treatment.Results The differences of brain edema,NIH stroke score,BI index scoreand,serum NO,TNF-αand IL-6 levels between after treatment and before treatment in the observation group were(4.75±2.21)mL,(6.25±2.21)score,(35.29±21.79)score,(4.33±1.15)pg/mL,(4.64±1.73)pg/mL and(8.33±4.17)pg/mL respectively;which in the control group were(7.11±3.09)mL,(7.85±2.69)score,(32.87±20.34)score,(8.02±4.54)pg/mL,(5.76±2.78)pg/mL and(20.11±10.29)pg/mL respectively,the differences between the two groups had statistical significance(P<0.05).Conclusion Aescinate combined with edaravone has a significant effect in the treatment of cerebral hemorrhage and is worthy of clinical promotion and application.更多还原