【摘要】 目的探讨血肌酐水平升高对急性冠脉综合征患者预后的影响。方法以2000年6月至2013年6月住院治疗且病历资料完整的急性冠脉综合征患者645例为研究对象,将住院期间血清肌酐水平较入院时增加25%的患者纳入肌酐增高组,其他患者纳入肌酐未升高组。采用Logistic回归模型分析肌酐水平与患者预后的关系。结果 645例患者中,33例纳入肌酐水平增高组,612例纳入肌酐水平未增高组。肌酐水平增高组患者院内全因病死率,以及心力衰竭、心源性休克发生率均高于肌酐水平未增高组(P<0.05)。Logistic回归分析显示,肌酐水平增高是急性冠脉综合征患者预后不良的预测因素(比值比为15.02,95%置信区间为10.64~40.05,P<0.05)。结论血清肌酐水平增高是急性冠脉综合征患者院内死亡及心血管不良事件的预测因素之一。更多还原

【Abstract】 Objective To explore the association between serum creatinine level and the prognosis of patients with acute coronary syndrome(ACS).Methods A total of 645 ACS patients,treated during Jun.2000 and Jun.2013,were enrolled in this study.Patients with creatinine level increased 25%compared between in-hospital level and that before treatment were divided into creatinine increased group,and the other patients were divided into creatinine notincreased group.Logistic analysis was used to analyze the relationship serum creatinine level and the in-hospital adverse events in ACS patients.Results Among all of the 645 ACS patients,33 cases were enrolled as creatinine increased group,and 612 patients were enrolled as creatinine not-increased group.Compared with patients in creatinine not-increase group,all cause mortality and incidence of heart failure and cardiogenic shock in creatinine increased group were higher(P<0.05).Logistic analysis revealed that increased creatinine level was a predictor of adverse events in patients suffered from ACS(odds ratio of 15.02,95%confidence interval of 10.64-40.05,P<0.05).Conclusion Increased serum creatinine levels could be one predictor of adverse events in ACS patients.更多还原