【摘要】 目的探讨红细胞分布宽度(RDW)和血小板分布宽度(PDW)对心肌梗死的预测价值。方法收集2011年11月至2013年10月以心肌梗死收治入重庆医科大学北碚附属医院的85例患者,回归性分析在心肌梗死发作前1~3个月测定的RDW值和PDW值与同时期健康对照组27例体检者的差异。结果采用SPSS17.0进行统计分析。结果心肌梗死组患者RDW值为(47.92±7.56)%和PDW值为(15.75±3.55)%,明显高于对照组的RDW值[(42.65±2.40)%]和PDW值[(13.52±1.94)%],差异有统计学意义(P<0.05)。心肌梗死组患者RDW值分别与PDW值和年龄存在明显的线性正相关(P<0.05),且该组中女性PDW值明显高于男性(P<0.01)。经多因素Logistic回归分析,RDW值和PDW值升高是发生心肌梗死的独立危险因素。RDW值预测发生心肌梗死的受试者工作特征曲线(ROC)下面积为0.767(95%CI 0.692~0.842),临界值为44.8%,对应的预测灵敏度为64.3%,特异度为88.9%。PDW值预测发生心肌梗死的ROC下面积为0.675(95%CI 0.583~0.766),临界值为14.9%,对应预测灵敏度为61.2%,特异度为58.1%。结论 RDW值和PDW值能较好地预测心肌梗死的发病风险。更多还原

【Abstract】 Objective To explore the predictive value of red blood cell distribution width(RDW)and platelet distribution width(PDW)in myocardial infarction.Methods Eighty five patients with myocardial infarction in Beibei Affiliated Hospital of Chongqing Medical University were selected as myocardial infarction group(MI group),in which RDW,PDW had been detected one to three months before attack and compared with those of the control group included 27healthy persons.SPSS17.0was used to analyze the results.Results The RDW,PDW levels of MI group were(47.92%±7.56%,P<0.01),(15.75%±3.55%,P<0.05)respectively,which were significantly higher than those of the control group which were(42.65%±2.40%),(13.52%±1.94%)respectively.Pearson correlation analysis showed that PDW level(P<0.05)and age(P<0.05)had positive correlation with RDW level in MI group. An independent sample test showed that PDW level of women was significantly higher than that of Men in MI group(P<0.01).In multivariate Logistic analyses,higher levels of PDW and RDW were independent risk factors of myocardial infarction.The area under receiver operating characteristics curve(AUC)of prediction myocardial infarction of RDW level was 0.767(95%CI0.692-0.842),the corresponding Cut-off point was 44.8% with sensitivity 64.3% and specificity 88.9%.The AUCof prediction myocardial infarction of PDW level was 0.675(95%CI 0.583-0.766),the corresponding Cut-off point was 14.9% with sensitivity 61.2% and specificity 58.1%.ConclusionRDW and PDW could be a good predictive marker for myocardial infarction.更多还原