【摘要】 目的:检测溃疡性结肠炎患者血清可溶性细胞间粘附分子-1(sICAM-1)水平的变化,探讨sICAM-1对溃疡性结肠炎疾病进展程度的作用。方法:溃疡性结肠炎32例、健康体检者20例为研究对象,采用ELISA法检测血清SICAM-1水平,分析其与临床分型、病变范围、疾病严重程度、肠外表现与CRP、ESR的关系。结果:(1)sICAM-1水平:溃疡性结肠炎组305.34±73.33ng/mL,对照组189.72±56.46ng/mL,两组比较差异有统计学意义(P<0.05)。(2)sICAM-1与临床分型关系:初发型15例sICAM-1 283.45±90.02ng/mL,慢性反复发作型17例sICAM-1为292.36±78.91ng/mL,两者比较差异无统计学意义(P>0.05)。(3)sICAM-1与病变范围关系:E1(直肠)14例,E2(左半结肠)12例,E3(广泛结肠)6例,其sICAM-1分别为264.22±89.43ng/mL、275.36±97.91ng/mL、336.45±73.02ng/mL,E1组与E2组比较差异无统计学意义(P>0.05),E3组与E1、E2组比较差异有统计学意义(P<0.05)。(4)sICAM-1与疾病程度关系:轻度10例,中度16例,重度6例,其sICAM-1分别264.22±67.27ng/mL、302.36±54.34ng/mL、336.45±73.02ng/mL,3组间比较差异有统计学意义(P<0.05)。(5)sICAM-1肠外表现:肠外表现11例,sICAM-1为312.23±89.02ng/mL。无肠外表现21例sICAM-1为295.11±65.02ng/mL,两者比较差异无统计学意义(P>0.05)。(6)sICAM-1水平与CRP、ESR的关系:sICAM-1与CRP成正相关,r值为0.561(P<0.05);sICAM-1与ERS成正相关,r值为0.478(P<0.05)。结论:sICAM-1水平与UC病变范围及严重程度相关,可作为评估UC炎症程度指标之一。更多还原

【Abstract】 Objective:To determine the serum levels of intercellular adhesion molecule-1(sICAM-1) in patients with ulcerative colitis and to investigate the contributions of sICAM-1 in pathogenesis of UC. Methods: The serum ICAM-1 concentrations were determined by enzyme-linked immunosorbent assay in 32 patients with UC and 20 healthy controls at the time of admission.The relationships between the sICAM-1 levels and the clinical type, the extent, the severity, Extraintestinal complications, CRP and ESR were analized. Results:(1)the levels of sICAM-1:The mean value of sICAM-1 level in the UC group(305.34±73.33ng/mL)was significantly higher than in the health group(189.72±56.46ng/mL)(P<0.05).(2) the relationgships between sICAM-1 and clinical classification: There were no remarkable relationships between the levels of sICAM-1 in 15 patients of the first attack group(283.45 ±90.02ng/mL) and 17 patients of the recurrent attack group(292.36±78.91ng/mL)(P>0.05).(3) the relationgships between sICAM-1 and the extent of disease:14 patients in E1(the rectal group),12 patients in E2(the sigmoid group),6 patients in E3(the extensive colonic group). There were no remarkable relationships between sICAM-1 in the E1 group(264.22±89.43ng/mL) and the E2 group(275.36±97.91ng/mL)(P> 0.05), but the levels of sICAM-1 in the E3(336.45±73.02ng/mL)group was significantly higher than in the E1group and the E2 group(P<0.05).(4) the relationgships between sICAM-1 and different degrees of severity of disease: 10 patients in the light group(264.22±67.27ng/mL), 16patients in the moderate group(302.36 ±54.34ng/mL), 6 patients in the severe group(336.45±73.02ng/mL), the levels of sICAM-1 between the three groups with differernt degrees of severity of UC were significantly different(P<0.05).(5) the relationgships between sICAM-1 and Extraintestinal complications : 11 patients with extraintestinal complications(312.23±89.02ng/mL), 21 patients without extraintestinal complications(295.11±65.02ng/mL), there were no remarkable relationships between sICAM-1 and Extraintestinal complications(P>0.05).(6) the relationgships between sICAM-1 and CRP and ESR: sICAM-1 was positively correlated with CRP(r=0.561,P<0.05)) and ESR(r=0.478,P <0.05). Conclusions: sICAM-1 levels were correlated with the extent and the severity of UC. The measurement of sICAM-1 may be valuable markers to evaluate the severity for patients with ulcerative colitis.更多还原