【摘要】 目的:探讨TRA2B在非小细胞肺癌中的表达情况,并分析其与肺癌临床病理特征之间的关系。方法:Western blot检测6对肺癌组织和癌旁非肿瘤组织中TRA2B的蛋白表达水平,免疫组织化学染色分析93例非小细胞肺癌组织中TRA2B的表达。结果:TRA2B在肺癌组织中表达水平高于癌旁非肿瘤组织,TRA2B的表达情况与肺癌的分化程度以及临床分级相关(P<0.05)。结论:TRA2B在非小细胞肺癌中表达上调,提示TRA2B可能可以作为诊断肺癌的潜在标记物以及治疗的潜在靶点。更多还原

【Abstract】 Objective: To analyze the expression of TRA2B in Non-small cell lung cancer and the relationship between the expression of TRA2B and its clinicopathologic variables. Methods: The expression of TRA2B in 6 pairs of tumor tissues and adjacent nontumorous tissues was detected by Western blot, and immunohistochemistry technique was used to analyze the expression of TRA2B in 93 lung cancer samples. Results: The expression of TRA2B was higeher in lung cancer tissues than in adjacent nontumorous tissues and the expression of TRA2B had a correlation with the clinical stage and histological differentiation. Conclusion: TRA2B was overexpressed in lung cancer and TRA2B might be a potential marker for lung cancer diagnosis and a potential target for lung cancer therapy.更多还原