【摘要】 研究HIV-1蛋白酶的剪切特异性是研制蛋白酶抑制剂类药物的基础。针对HIV-1蛋白酶剪切位点预测改进一种新型的过滤器方法,去除特征集中的冗余特征,简化分类器结构。通过融合三种特征获得完备的特征表达并对支持向量机(SVM)进行参数优化从而提高预测性能。结果表明该方法的预测性能优于当前基于特征提取的研究成果,这表明特征选择结合特征融合并且进行SVM参数优化可以有效提高HIV-1蛋白酶剪切位点预测效果,能够为未来开发HIV-1蛋白酶抑制剂提供有用的帮助。更多还原

【Abstract】 Understanding the specificity of HIV-1 protease is crucial for designing HIV-1 protease inhibitors. A filter feature selection method was improved specially for HIV-1 protease cleavage site prediction, thus the redundant features were eliminated and the classifier was simplified. Three kinds of features were fused to make sure comprehensive feature representation and parameter optimization for Support Vector Machine( SVM) was conducted in order to improve prediction capability. The experiment results show that the method used in this paper gains better performance than the state-of-the-art researches based on feature extraction. This means feature selection combining feature fusion with classifier parameter optimization can effectively improve HIV-1 cleavage site prediction performance. Moreover the work in this paper can provide useful help for HIV-1 protease inhibitor developing in the future.更多还原