【摘要】 目的:观察外用氨基酮戊酸光动力疗法(ALA-PDT)联合CO2激光治疗肛管尖锐湿疣的临床疗效。方法:84例肛管尖锐湿疣患者随机分为治疗组及对照组各42例,治疗组接受ALA-PDT联合CO2激光治疗,每周1次,连续3次,对照组接受CO2激光治疗,每周1次,连续3次。末次治疗后第1周进行疗效评价,第4、8和12周观察复发率。治疗前及末次治疗后1周进行实验室检查,并观察不良反应。结果:在末次治疗后1周,治疗组和对照组疣体清除率分别为100%和97.62%(P>0.05)。治疗组治疗后总复发率(11.9%)明显低于对照组(35.71%)(P=0.010 4<0.05)。治疗组及对照组均未发生严重的不良反应,主要的不良反应包括红斑、疼痛、溃疡和疤痕等。结论:外用ALA-PDT联合CO2激光治疗肛管尖锐湿疣的治愈率高,复发率低,安全性好。更多还原

【Abstract】 Objective To investigate the safety and efficacy of topical aminolevulinic acid photodynamic therapy (ALA-PDT) combined with carbon dioxide laser in the treatment of anal tube condyloma acuminatum.Method Eighty-four patients with anal tube condyloma acuminatum were randomly assigned to the treatment group and control group in an allocation ratio of 1:1.The treatment group was treated with ALA-PDT combined with carbon dioxide laser weekly for 3 times.The control group was treated with carbon dioxide laser weekly for 3 times.The recurrence rate was evaluated at weeks 4,8,and l2 after the treatment ended.Results At l week after the last treatment 100% and 97.62% of the base line warts were eliminated in the treatment group and the control group respectively (P > 0.05) .The overall recurrence rate of the treatment group was significantly lower than that in the control group (11.9% Vs 35.7%,P = 0.010 4) .There was no severe adverse event in either group.The main adverse event were mild symptoms including erythema,pain,ulcer and scarring.Conclusion Our results confirmed that ALA-PDT combined with carbon dioxide laser is an effective,safe and well-tolerated treatment for anal tube condylomata acuminata.更多还原