【摘要】 microRNA(miRNA)是一种新型的小分子非编码RNA,对基因表达具有非常重要的调控作用。miR-150是一个长度为22个核苷酸的非编码小分子RNA,定位于人类染色体19q13.33,主要通过调控其靶基因的表达,在免疫系统、造血系统发生、胚胎发育和干细胞分化中发挥重要作用,并在许多疾病中发生异常表达,提示miR-150与疾病的发生与发展密切相关。本文就miR-150在人体正常生理过程中的作用以及异常表达引起的机体变化和可能的作用机制作一综述。更多还原

【Abstract】 MicroRNA( miRNA) is a novel type of non-coding RNA which can play very important roles in regulating gene expression. Early studies found that miR-150 is a 22 nt non-coding RNA,and located on Chromosome 19. It plays key roles in immune system,hematopoietic system progressive,embryonic development and stem cells differention by regulating the expression of its target mRNA. Recent investigations suggest that miR-150 expresses abnormally in different diseases. This reveals that miR-150 is closed related to the occurrence and development of many diseases. This article reviews the effect of miR-150 in human normal physiological processes,its abnormal expressions inducing changes in body and the possible mechanism involved.更多还原