【摘要】 目的:探讨槲皮素对非沉积高尿酸血症致肾损伤的保护作用。方法:成年雄性Wistar大鼠随机分成对照组、模型组、槲皮素组。氧嗪酸钾灌饲法制备大鼠高尿酸血症肾损伤模型,槲皮素预防治疗5周,测定24小时尿蛋白、血清及肾组织生化指标,同时进行肾脏病理学研究。结果:与模型组相比,槲皮素降低了血尿酸(SUA)、血尿素氮(BUN)、血肌酐(SCr)以及血清和肾组织中白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及丙二醛(MDA)的水平,并能提高血清和肾组织中超氧化物歧化酶(SOD)的活性。槲皮素组的肾脏病理损伤也获得缓解。结论:槲皮素对非沉积高尿酸血症所致的肾损伤具有保护作用,这种保护作用可能与槲皮素的降尿酸、抗炎、抗氧化作用有关。更多还原

【Abstract】 Objective:Study the protective effect of quercetin from renal injury induced by non-crystal hyperuricemia.Methods:Male ault wistar rats were randomly assigned into three groups:control group,model group and quercetin group.Daily gavage with oxonic acid potassium was used to build non-crystal hyperuricemic rat model,using quercetin to prevention treat for 5weeks.Biochemical and pathology study were carried out.Results:Compared to model group,quercetin reduced the levels of 24hurinary protein uric acid,creatinine,blood urea nitrogen,blood and renal interleukin-6,tumor necrosis factor-αand malondialdehyde,and increased the activity of superoxide dismutase in blood and kidney.There is marked renal injury in the non-crystal hyperuricemic group,which is reduced in the quercetin group.Conclusions:Quercetin can protect kidney from renal injury induced by non-crystal hyperuricemia,which is associated with its lower uric acid,antiinflammatory and antioxidative effect.更多还原