【摘要】 目的系统评价认知行为疗法用于治疗抗精神病药物所致体重增加的效果。方法计算机检索2000年1月-2012年12月MEDLINE、Cochrane图书馆、中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库,收集关于认知行为疗法治疗抗精神病药物所致体重增加的随机对照试验。由两名研究者独立进行文献筛选、资料提取和文献质量评价,采用RevMan5.0软件对资料进行Meta分析。结果最终纳入6篇随机对照研究,包括295名受试者。结果显示,治疗结束时研究组体重低于对照组[WMD=-1.83 Kg,95%CI(-2.79,-0.88)Kg],差异有统计学意义(P<0.01),治疗结束时研究组体重指数低于对照组[WMD=-0.69 Kg/m2,95%CI(-1.04,-0.34)Kg/m2],差异有统计学意义(P<0.01)。结论现有的研究显示,认知行为疗法能够改善抗精神病药物所致体重增加。更多还原

【Abstract】 Objective To assess whether cognitive behavioral therapy prevents body weight gain in persons with serious mental illness who are treated with antipsychotics. Methods The randomized controlled trials( RCT) about cognitive behavioral therapy for prevention of weight gain with antipsychotics from January 2000 to December 2012 were selected in the Medline,Cochrane Library,CNKI,VIP and Wanfang Data. Two reviewers independently screened the literatures,extracted the data,and evaluated the methodological quality. The meta- analyses were conducted by using RevMan 5. 0 software. Results The total 6 RCTs were selected and 295 patients were involved. The results of meta- analyses showed that the efficacy of the cognitive behavioral group was superior to that of the control group in lessen body mass[WMD =-1. 83 Kg,95% CI(-2. 79,-0. 88) Kg,( P < 0. 01) ],BWI[WMD =-0. 69 Kg /m2,95%CI(-1.04,-0.34)Kg / m2( P <0.01) ]with significant differences. Conclusion Cognitive behavioral therapy is effective in attenuating antipsychotics-induced weight gain.更多还原