节点文献

布洛芬速释固体分散体的制备及体外溶出度研究

Research on Preparation and Dissolution Rate of Immediate-release Solid Dispersion of Ibuprofen

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 金刚王洁展瑞岩薛健飞张艳陈帅

【Author】 JIN Gang;WANG Jie;ZHAN Rui-yan;XUE Jian-fei;ZHANG Yan;CHEN Shuai;College of Chemical and Pharmaceutical Engineering,Jilin Institute of Chemical Technology;

【机构】 吉林化工学院化学与制药工程学院

【摘要】 目的:制备布洛芬速释固体分散体来提高其水溶性.方法:通过测定布洛芬在各种辅料水溶液的溶解度,及固体分散体在水中的溶出度来选择最优载体及表面活性剂.首先将药物缓慢加入到不断搅拌的无水乙醇中,完全溶解后再分别加入载体、表面活性剂和少量的蒸馏水,充分混匀后水浴加热蒸去大部分有机溶剂后放入40℃干燥箱内进行干燥,排除剩余溶剂,既得布洛芬固体分散体,测定原料药、物理混合物及固体分散体的体外溶出度.结果:当以聚乙烯吡咯烷酮k30(PVPk30)为载体,十二烷基硫酸钠(SDS)为表面活性剂时,且药物:PVPk30SDS=1 7时药物呈现了很好的水溶性.在2h内即可溶出80%.很大程度上提高了布洛芬的体外溶出度.

【Abstract】 OBJECTIVE: Preparing the immediate-release solid dispersions of ibuprofen to enhance the watersolubility. METHODS: The optimal carrier and surfactant were chose from the solubility and dissolution test,immediate-release solid dispersions of ibuprofen have been prepared by solvent method,First added the drug into the anhydrous ethanol,after that added the carriers,surfactant and a little distilled water keep mixing until dissolved completely. Then the solid dispersion after drying on the water bath is obtained,then put it in the 40℃ dryer until the solvents were eliminated. Measuring the dissolution rate of the pure drug,physical mixure and solid dispersion. CONCLUSION: The dissolution rate improved to the 80% during 2 h,when used PVPk30 as the carriers,SDS as the surfactant and the ratio of drug: PVPk30: SDS was 1: 7: 1% in the solid dispersion system. The dissolution rate of the drug has been increased significantly.

  • 【文献出处】 吉林化工学院学报 ,Journal of Jilin Institute of Chemical Technology , 编辑部邮箱 ,2014年07期
  • 【分类号】TQ463
  • 【被引频次】1
  • 【下载频次】434
节点文献中: 

本文链接的文献网络图示:

本文的引文网络