【摘要】 目的:探讨细胞周期调节蛋白Stathmin与早期自然流产发生的相关性。方法:选取行人工流产负压吸宫手术(A组)和先兆流产(B组)妇女各30例,收集其绒毛和蜕膜组织,采用蛋白免疫印迹法和免疫组织化学法检测两组妇女绒毛和蜕膜组织中Stathmin的表达水平。结果:Stathmin主要表达于绒毛和蜕膜组织的细胞浆中,Stathmin在A组绒毛组织中的阳性表达比例为25/30,在蜕膜组织中的阳性表达比例为23/30;在B组绒毛组织中的阳性表达比例为17/30,在蜕膜组织中的阳性表达比例为14/30。A组绒毛和蜕膜组织中Stathmin的表达显著高于B组相应组织中的表达(P均<0.01)。结论:Stathmin可能与早期自然流产的病理发生相关。更多还原

【Abstract】 Objective:To investigate the correlation between the expression of Stathmin and the pathogenesis of early spontaneous abortion.Methods:The expression of Stathmin in the villus and decidua tissues of women presenting for early spontaneous abortion(n=30,group A)and seeking for early artificial abortion(n=30,group B)were detected by the methods of Western blotting and immunohistochemistry.Results:The result of immunohistochemistry showed that Stathmin was positive expressed mainly in cytoplasm of the villus and decidua cells.The positive expression rates of Stathmin in the villus tissues were 25/30in group A and 17/30in group B.The positive expression rates of Stathmin in the decidua tissues were 23/30in group A and 14/30in group B.The expression levels of Stathmin in the villus and decidua tissues of group A was significantly higher than those of group B(both P<0.01).Conclusion:Stathmin may be revolved in the pathogenesis of early spontaneous abortion.更多还原